Methotrexate-Associated Nonalcoholic Fatty Liver Disease with Transaminitis in Rheumatoid Arthritis
Joint Authors
Sakthiswary, Rajalingham
Chan, Grace Yin Lai
Koh, Ee Tzun
Leong, Khai Pang
Thong, Bernard Yu Hor
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Background.
The aim of this study was to determine the risk factors of MTX-associated nonalcoholic fatty liver disease (NAFLD) with transaminitis in a cohort of rheumatoid arthritis (RA) patients from Singapore.
Methods.
Patients who developed ultrasound proven NAFLD with transaminitis while on MTX therapy were identified.
The demographic and clinical characteristics of the above patients (cases) were compiled and compared with age- and gender-matched controls who were RA patients on long standing MTX therapy without any episode of transaminitis.
Results.
Among the 978 patients who had received MTX, the prevalence of MTX-associated NAFLD was 4.7% (46 patients).
Compared to the controls, the cases had significantly higher mean cumulative dose of MTX (4.03 ± 2.25 g versus 10.04 ± 9.94 g, P≤0.05), weekly dose of MTX (11.3 ± 4.8 mg versus 13.1 ± 4.4 mg weekly, P=0.033), and fasting blood glucose (P=0.029).
Following multivariate regression analysis, only cumulative dose of MTX remained significant (P=0.015).
Among the cases, the cumulative dose of MTX was found to have a significant positive correlation with the alanine transaminase (ALT) level (P<0.05, standardised beta coefficient 0.512).
Conclusion.
The cumulative dose of MTX was the only independent predictor of MTX-associated NAFLD with transaminitis.
American Psychological Association (APA)
Sakthiswary, Rajalingham& Chan, Grace Yin Lai& Koh, Ee Tzun& Leong, Khai Pang& Thong, Bernard Yu Hor. 2014. Methotrexate-Associated Nonalcoholic Fatty Liver Disease with Transaminitis in Rheumatoid Arthritis. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1051205
Modern Language Association (MLA)
Sakthiswary, Rajalingham…[et al.]. Methotrexate-Associated Nonalcoholic Fatty Liver Disease with Transaminitis in Rheumatoid Arthritis. The Scientific World Journal No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1051205
American Medical Association (AMA)
Sakthiswary, Rajalingham& Chan, Grace Yin Lai& Koh, Ee Tzun& Leong, Khai Pang& Thong, Bernard Yu Hor. Methotrexate-Associated Nonalcoholic Fatty Liver Disease with Transaminitis in Rheumatoid Arthritis. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1051205
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051205