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Differences of Various Region-of-Interest Methods for Measuring Dopamine Transporter Availability Using Tc99m-TRODAT-1 SPECT
Joint Authors
Yin, Tang-Kai
Lee, Bi-Fang
Yang, Yen Kuang
Chiu, Nan-Tsing
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
This study was to investigate whether various region-of-interest (ROI) methods for measuring dopamine transporter (DAT) availabilities by single photon emission computed tomography (SPECT) are statistically different, whether results of medical research are thereby influenced, and causes of these differences.
Eighty-four healthy adults with Tc99m-TRODAT-1 SPECT and magnetic resonance imaging (MRI) scans were included.
Six major analysis approaches were compared: (1) ROI drawn on the coregistered MRI; (2) ROIs drawn on the SPECT images; (3) standard ROI templates; (4) threshold-ROIs; (5) atlas-based mappings with coregistered MRI; and (6) atlas-based mappings with SPECT images.
Using the atlas-based approaches we assessed the influence of striatum ROIs by slice-wise and voxel-wise comparisons.
In (5) and (6), three partial-volume correction (PVC) methods were also explored.
The results showed that DAT availabilities obtained from different methods were closely related but quite different and leaded to significant differences in determining the declines of DAT availability per decade (range: 5.95–11.99%).
Use of 3D whole-striatum or more transverse slices could avoid biases in measuring the striatal DAT declines per decade.
Atlas-based methods with PVC may be the preferable methods for medical research.
American Psychological Association (APA)
Yin, Tang-Kai& Lee, Bi-Fang& Yang, Yen Kuang& Chiu, Nan-Tsing. 2014. Differences of Various Region-of-Interest Methods for Measuring Dopamine Transporter Availability Using Tc99m-TRODAT-1 SPECT. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1051273
Modern Language Association (MLA)
Yin, Tang-Kai…[et al.]. Differences of Various Region-of-Interest Methods for Measuring Dopamine Transporter Availability Using Tc99m-TRODAT-1 SPECT. The Scientific World Journal No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1051273
American Medical Association (AMA)
Yin, Tang-Kai& Lee, Bi-Fang& Yang, Yen Kuang& Chiu, Nan-Tsing. Differences of Various Region-of-Interest Methods for Measuring Dopamine Transporter Availability Using Tc99m-TRODAT-1 SPECT. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1051273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051273