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Correlations of Ezrin Expression with Pathological Characteristics and Prognosis of Osteosarcoma: A Meta-Analysis
Joint Authors
Zhao, Da-Hang
Zhu, Jiang
Wang, Wen-Bo
Dong, Feng
Zhang, Qiao
Fan, Hong-Wu
Zhang, Jing-Zhe
Wang, Yong-Ming
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
We conducted a meta-analysis to comprehensively evaluate the correlations of ezrin expression with pathological characteristics and the prognosis of osteosarcoma.
The MEDLINE (1966–2013), the Cochrane Library Database, EMBASE, CINAHL, Web of Science (1945–2013), and the Chinese Biomedical Database were searched without language restrictions.
Meta-analyses conducted using STATA software were calculated.
Ten studies met the inclusion criteria, including 459 patients with osteosarcoma.
Meta-analysis results illustrated that ezrin expression may be closely associated with the recurrence of osteosarcoma or metastasis in osteosarcoma.
Our findings also demonstrated that patients with grade III-IV osteosarcoma showed a higher frequency of ezrin expression than those with histological grade I-II osteosarcoma.
Furthermore, we found that patients with positive expression of ezrin exhibited a shorter overall survival than those with negative ezrin expression.
The results also indicated that positive ezrin expression was strongly correlated with poorer metastasis-free survival.
Nevertheless, no significant relationships were observed between ezrin expression and clinical variables (age and gender).
In the current meta-analysis, our results illustrated significant relationships of ezrin expression with pathological characteristics and prognosis of osteosarcoma.
Thus, ezrin expression could be a promising marker in predicting the clinical outcome of patients with osteosarcoma.
American Psychological Association (APA)
Zhao, Da-Hang& Zhu, Jiang& Wang, Wen-Bo& Dong, Feng& Zhang, Qiao& Fan, Hong-Wu…[et al.]. 2014. Correlations of Ezrin Expression with Pathological Characteristics and Prognosis of Osteosarcoma: A Meta-Analysis. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1051274
Modern Language Association (MLA)
Zhao, Da-Hang…[et al.]. Correlations of Ezrin Expression with Pathological Characteristics and Prognosis of Osteosarcoma: A Meta-Analysis. The Scientific World Journal No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1051274
American Medical Association (AMA)
Zhao, Da-Hang& Zhu, Jiang& Wang, Wen-Bo& Dong, Feng& Zhang, Qiao& Fan, Hong-Wu…[et al.]. Correlations of Ezrin Expression with Pathological Characteristics and Prognosis of Osteosarcoma: A Meta-Analysis. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1051274
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051274