Functional Stability of Plasminogen Activator Inhibitor-1
Joint Authors
Yasar Yildiz, Songul
Kuru, Pinar
Toksoy Oner, Ebru
Agirbasli, Mehmet
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of plasminogen activators, such as tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA), and a major regulator of the fibrinolytic system.
PAI-1 plays a pivotal role in acute thrombotic events such as deep vein thrombosis (DVT) and myocardial infarction (MI).
The biological effects of PAI-1 extend far beyond thrombosis including its critical role in fibrotic disorders, atherosclerosis, renal and pulmonary fibrosis, type-2 diabetes, and cancer.
The conversion of PAI-1 from the active to the latent conformation appears to be unique among serpins in that it occurs spontaneously at a relatively rapid rate.
Latency transition is believed to represent a regulatory mechanism, reducing the risk of thrombosis from a prolonged antifibrinolytic action of PAI-1.
Thus, relying solely on plasma concentrations of PAI-1 without assessing its function may be misleading in interpreting the role of PAI-1 in many complex diseases.
Environmental conditions, interaction with other proteins, mutations, and glycosylation are the main factors that have a significant impact on the stability of the PAI-1 structure.
This review provides an overview on the current knowledge on PAI-1 especially importance of PAI-1 level and stability and highlights the potential use of PAI-1 inhibitors for treating cardiovascular disease.
American Psychological Association (APA)
Yasar Yildiz, Songul& Kuru, Pinar& Toksoy Oner, Ebru& Agirbasli, Mehmet. 2014. Functional Stability of Plasminogen Activator Inhibitor-1. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1051369
Modern Language Association (MLA)
Yasar Yildiz, Songul…[et al.]. Functional Stability of Plasminogen Activator Inhibitor-1. The Scientific World Journal No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1051369
American Medical Association (AMA)
Yasar Yildiz, Songul& Kuru, Pinar& Toksoy Oner, Ebru& Agirbasli, Mehmet. Functional Stability of Plasminogen Activator Inhibitor-1. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1051369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051369