Interaction between DNA and Trimethyl-Ammonium Bromides with Different Alkyl Chain Lengths
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The interaction between λ—DNA and cationic surfactants with varying alkyl chain lengths was investigated.
By dynamic light scattering method, the trimethyl-ammonium bromides-DNA complex formation was shown to be dependent on the length of the surfactant’s alkyl chain.
For surfactants with sufficient long alkyl chain (CTAB, TTAB, DTAB), the compacted particles exist with a size of ~60–110 nm at low surfactant concentrations.
In contrast, high concentration of surfactants leads to aggregates with increased sizes.
Atomic force microscope scanning also supports the above observation.
Zeta potential measurements show that the potential of the particles decreases with the increase of surfactant concentration (CTAB, TTAB, DTAB), which contributes much to the coagulation of the particles.
For OTAB, the surfactant with the shortest chain in this study, it cannot fully neutralize the charges of DNA molecules; consequently, the complex is looser than other surfactant-DNA structures.
American Psychological Association (APA)
Cheng, Chao& Ran, Shi-Yong. 2014. Interaction between DNA and Trimethyl-Ammonium Bromides with Different Alkyl Chain Lengths. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1051391
Modern Language Association (MLA)
Cheng, Chao& Ran, Shi-Yong. Interaction between DNA and Trimethyl-Ammonium Bromides with Different Alkyl Chain Lengths. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1051391
American Medical Association (AMA)
Cheng, Chao& Ran, Shi-Yong. Interaction between DNA and Trimethyl-Ammonium Bromides with Different Alkyl Chain Lengths. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1051391
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051391