Antinociceptive and Antioxidant Activity of Zanthoxylum budrunga Wall (Rutaceae) Seeds
Joint Authors
Islam, Md. Khirul
Biswas, Nripendra Nath
Saha, Sanjib
Hossain, Hemayet
Jahan, Ismet Ara
Khan, Tanzir Ahmed
Shilpi, J. A.
Awang, Khalijah
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Different parts of the medicinal plant Zanthoxylum budrunga Wall enjoy a variety of uses in ethnobotanical practice in Bangladesh.
In the present study, a number of phytochemical and pharmacological investigations were done on the ethanol extract of Z.
budrunga seeds (ZBSE) to evaluate its antinociceptive and antioxidant potential.
ZBSE was also subjected to HPLC analysis to detect the presence of some common antioxidants.
In acetic acid induced writhing test in mice, ZBSE showed 65.28 and 74.30% inhibition of writhing at the doses of 250 and 500 mg/kg and the results were statistically significant ( P < 0.001 ).
In hot-plate test, ZBSE raised the pain threshold significantly ( P < 0.001 ) throughout the entire observation period.
In DPPH scavenging assay, the IC50 of ZBSE was observed at 82.60 μ g/mL.
The phenolic content was found to be 338.77 mg GAE/100 g of dried plant material.
In reducing power assay, ZBSE showed a concentration dependent reducing ability.
HPLC analysis indicated the presence of caffeic acid with a concentration of 75.45 mg/100 g ZBSE.
Present investigation supported the use of Zanthoxylum budrunga seed in traditional medicine for pain management.
Constituents including caffeic acid and other phenolics might have some role in the observed activity.
American Psychological Association (APA)
Islam, Md. Khirul& Biswas, Nripendra Nath& Saha, Sanjib& Hossain, Hemayet& Jahan, Ismet Ara& Khan, Tanzir Ahmed…[et al.]. 2014. Antinociceptive and Antioxidant Activity of Zanthoxylum budrunga Wall (Rutaceae) Seeds. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051420
Modern Language Association (MLA)
Islam, Md. Khirul…[et al.]. Antinociceptive and Antioxidant Activity of Zanthoxylum budrunga Wall (Rutaceae) Seeds. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1051420
American Medical Association (AMA)
Islam, Md. Khirul& Biswas, Nripendra Nath& Saha, Sanjib& Hossain, Hemayet& Jahan, Ismet Ara& Khan, Tanzir Ahmed…[et al.]. Antinociceptive and Antioxidant Activity of Zanthoxylum budrunga Wall (Rutaceae) Seeds. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051420
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051420