![](/images/graphics-bg.png)
Expression of Angiogenesis Regulatory Proteins and Epithelial-Mesenchymal Transition Factors in Platelets of the Breast Cancer Patients
Joint Authors
Han, Hui
Cao, Fang-Li
Wang, Bao-Zhong
Mu, Xue-Ru
Li, Guang-Yao
Wang, Xiu-Wen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Platelets play a role in tumor angiogenesis and growth and are the main transporters of several angiogenesis regulators.
Here, we aimed to determine the levels of angiogenesis regulators and epithelial-mesenchymal transition factors sequestered by circulating platelets in breast cancer patients and age-matched healthy controls.
Platelet pellets (PP) and platelet-poor plasma (PPP) were collected by routine protocols.
Vascular endothelial growth factor (VEGF), platelet-derived growth factor BB (PDGF-BB), thrombospondin-1 (TSP-1), platelet factor 4 (PF4), and transforming growth factor-β1 (TGF-β1) were measured by enzyme-linked immunosorbent assay.
Angiogenesis-associated expression of VEGF (2.1 pg/106 platelets versus 0.9 pg/106 platelets, P < 0.001), PF4 (21.2 ng/106 platelets versus 10.2 ng/106 platelets, P < 0.001), PDGF-BB (42.9 pg/106 platelets versus 19.1 pg/106 platelets, P < 0.001), and TGF-β1 (15.3 ng/106 platelets versus 4.3 ng/106 platelets, P < 0.001) differed in the PP samples of cancer and control subjects.
In addition, protein concentrations were associated with clinical characteristics (P<0.05).
Circulating platelets in breast cancer sequester higher levels of PF4, VEGF, PDGF-BB, and TGF-β1, suggesting a possible target for early diagnosis.
VEGF, PDGF, and TGF-β1 concentrations in platelets may be associated with prognosis.
American Psychological Association (APA)
Han, Hui& Cao, Fang-Li& Wang, Bao-Zhong& Mu, Xue-Ru& Li, Guang-Yao& Wang, Xiu-Wen. 2014. Expression of Angiogenesis Regulatory Proteins and Epithelial-Mesenchymal Transition Factors in Platelets of the Breast Cancer Patients. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051457
Modern Language Association (MLA)
Han, Hui…[et al.]. Expression of Angiogenesis Regulatory Proteins and Epithelial-Mesenchymal Transition Factors in Platelets of the Breast Cancer Patients. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1051457
American Medical Association (AMA)
Han, Hui& Cao, Fang-Li& Wang, Bao-Zhong& Mu, Xue-Ru& Li, Guang-Yao& Wang, Xiu-Wen. Expression of Angiogenesis Regulatory Proteins and Epithelial-Mesenchymal Transition Factors in Platelets of the Breast Cancer Patients. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051457
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051457