The Feasibility of Using CT-Guided ROI for Semiquantifying Striatal Dopamine Transporter Availability in a Hybrid SPECTCT System
Joint Authors
Chang, Yen-Hsiang
Tang, Shu-Wen
Lin, Wei-Che
Chiu, Nan-Tsing
Wang, Pei-Wen
Huang, Yung-Cheng
Hsu, Chien-Chin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
A hybrid SPECT/CT system provides accurate coregistration of functional and morphological images.
CT-guided region of interest (ROI) for semiquantifying striatal dopamine transporter (DAT) availability may be a feasible method.
We therefore assessed the intra- and interobserver reproducibility of manual SPECT and CT-guided ROI methods and compared their semiquantitative data with data from MRI-guided ROIs.
We enrolled twenty-eight patients who underwent Tc-99m TRODAT-1 brain SPECT/CT and brain MRI.
ROIs of the striatal, caudate, putamen, and occipital cortex were manually delineated on the SPECT, CT, and MRI.
ROIs from CT and MRI were transferred to the coregistered SPECT for semiquantification.
The striatal, caudate, and putamen nondisplaceable binding potential (BPND) were calculated.
Using CT-guided ROIs had higher intra- and interobserver concordance correlation coefficients, closer Bland-Altman biases to zero, and narrower limits of agreement than using manual SPECT ROIs.
The correlation coefficients of striatal, caudate, and putamen BPND were good between manual SPECT and MRI-guided ROI methods and even better between CT-guided and MRI-guided ROI methods.
Conclusively, CT-guided ROI delineation for semiquantifying striatal DAT availability in a hybrid SPECT/CT system is highly reproducible, and the semiquantitative data correlate well with data from MRI-guided ROIs.
American Psychological Association (APA)
Hsu, Chien-Chin& Chang, Yen-Hsiang& Lin, Wei-Che& Tang, Shu-Wen& Wang, Pei-Wen& Huang, Yung-Cheng…[et al.]. 2014. The Feasibility of Using CT-Guided ROI for Semiquantifying Striatal Dopamine Transporter Availability in a Hybrid SPECTCT System. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1051467
Modern Language Association (MLA)
Hsu, Chien-Chin…[et al.]. The Feasibility of Using CT-Guided ROI for Semiquantifying Striatal Dopamine Transporter Availability in a Hybrid SPECTCT System. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1051467
American Medical Association (AMA)
Hsu, Chien-Chin& Chang, Yen-Hsiang& Lin, Wei-Che& Tang, Shu-Wen& Wang, Pei-Wen& Huang, Yung-Cheng…[et al.]. The Feasibility of Using CT-Guided ROI for Semiquantifying Striatal Dopamine Transporter Availability in a Hybrid SPECTCT System. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1051467
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051467