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Antinociceptive and Anti-Inflammatory Activities of Bridelia retusa Methanolic Fruit Extract in Experimental Animals
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Antinociceptive and anti-inflammatory potentials of methanolic extract of Bridelia retusa fruit (BRME) were evaluated against different animal models in rodents.
Antinociceptive effects of BRME were assessed in mice using the acetic acid-induced writhing and formalin test.
Anti-inflammatory effects of BRME in three different doses, namely, 100, 200, and 400 mg/kg, were evaluated by utilizing different animal models representing various changes associated with inflammation, namely, carrageenan-induced paw oedema, histamine and serotonin-induced paw oedema, arachidonic acid-induced paw oedema, formalin-induced paw oedema, TPA-induced ear oedema, acetic acid-induced vascular permeability, total WBC count in paw fluid, and myeloperoxidase assay.
Also BRME was phytochemically evaluated using chromatographic method.
The BRME did not exhibit any signs of toxicity up to a dose of 2000 mg/kg.
The extract showed statistical significant inhibition of induced nociception and inflammation in dose dependent manner.
The higher dose of extract significantly inhibited pain and inflammation against control ( P < 0.001 ).
HPLC results revealed the presence of gallic acid and ellagic acid as phytoconstituents in BRME and it was proven as anti-inflammatory agents.
The present study scientifically demonstrated the antinociceptive and anti-inflammatory potential of fruit of B.
retusa methanolic extract.
These effects may be attributed to the presence of polyphenolic phytoconstituents in the extract.
American Psychological Association (APA)
Kumar, Tekeshwar& Jain, Vishal. 2014. Antinociceptive and Anti-Inflammatory Activities of Bridelia retusa Methanolic Fruit Extract in Experimental Animals. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1051470
Modern Language Association (MLA)
Kumar, Tekeshwar& Jain, Vishal. Antinociceptive and Anti-Inflammatory Activities of Bridelia retusa Methanolic Fruit Extract in Experimental Animals. The Scientific World Journal No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1051470
American Medical Association (AMA)
Kumar, Tekeshwar& Jain, Vishal. Antinociceptive and Anti-Inflammatory Activities of Bridelia retusa Methanolic Fruit Extract in Experimental Animals. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1051470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051470