Competing Endogenous RNA: The Key to Posttranscriptional Regulation
Joint Authors
Chakrabarti, Jayprokas
Sen, Rituparno
Ghosal, Suman
Das, Shaoli
Balti, Subrata
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Competing endogenous RNA, ceRNA, vie with messenger RNAs (mRNAs) for microRNAs (miRNAs) with shared miRNAs responses elements (MREs) and act as modulator of miRNA by influencing the available level of miRNA.
It has recently been discovered that, apart from protein-coding ceRNAs, pseudogenes, long noncoding RNAs (lncRNAs), and circular RNAs act as miRNA “sponges” by sharing common MRE, inhibiting normal miRNA targeting activity on mRNA.
These MRE sharing elements form the posttranscriptional ceRNA network to regulate mRNA expression.
ceRNAs are widely implicated in many biological processes.
Recent studies have identified ceRNAs associated with a number of diseases including cancer.
This brief review focuses on the molecular mechanism of ceRNA as part of the complex post-transcriptional regulatory circuit in cell and the impact of ceRNAs in development and disease.
American Psychological Association (APA)
Sen, Rituparno& Ghosal, Suman& Das, Shaoli& Balti, Subrata& Chakrabarti, Jayprokas. 2014. Competing Endogenous RNA: The Key to Posttranscriptional Regulation. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1051500
Modern Language Association (MLA)
Sen, Rituparno…[et al.]. Competing Endogenous RNA: The Key to Posttranscriptional Regulation. The Scientific World Journal No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1051500
American Medical Association (AMA)
Sen, Rituparno& Ghosal, Suman& Das, Shaoli& Balti, Subrata& Chakrabarti, Jayprokas. Competing Endogenous RNA: The Key to Posttranscriptional Regulation. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1051500
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051500