Investigation of the Effects of Curcumin on Serum Cytokines in Obese Individuals: A Randomized Controlled Trial
Joint Authors
Parizadeh, Seyyed Mohammad Reza
Sahebkar, Amirhossein
Ganjali, Shiva
Mahdipour, Elahe
Jamialahmadi, Khadijeh
Torabi, Sepideh
Akhlaghi, Saeed
Ghayour-Mobarhan, Majid
Ferns, Gordon
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Background.
Obesity is a disorder often accompanied by a heightened state of systemic inflammation and immunoactivation.
The present randomized crossover trial aimed to investigate the efficacy of curcumin, a bioactive polyphenol with established anti-inflammatory and immunomodulatory effects, on the serum levels of a panel of cytokines and mediators in obese individuals.
Methods.
Thirty obese individuals were randomized to receive curcumin at a daily dose of 1 g or a matched placebo for 4 weeks.
Following a 2-week wash-out period, each group was assigned to the alternate treatment regimen for another 4 weeks.
Serum samples were collected at the start and end of each study period.
Serum levels of IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, VEGF, IFNγ, EGF, MCP-1, and TNFα were measured using a multiplex Biochip Array Technology based method.
Results.
Mean serum IL-1β ( P = 0.042 ), IL-4 ( P = 0.008 ), and VEGF ( P = 0.01 ) were found to be significantly reduced by curcumin therapy.
In contrast, no significant difference was observed in the concentrations of IL-2, IL-6, IL-8, IL-10, IFNγ, EGF, and MCP-1.
Conclusions.
The findings of the present trial suggested that curcumin may exert immunomodulatory effects via altering the circulating concentrations of IL-1β, IL-4, and VEGF.
American Psychological Association (APA)
Ganjali, Shiva& Sahebkar, Amirhossein& Mahdipour, Elahe& Jamialahmadi, Khadijeh& Torabi, Sepideh& Akhlaghi, Saeed…[et al.]. 2014. Investigation of the Effects of Curcumin on Serum Cytokines in Obese Individuals: A Randomized Controlled Trial. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1051511
Modern Language Association (MLA)
Ganjali, Shiva…[et al.]. Investigation of the Effects of Curcumin on Serum Cytokines in Obese Individuals: A Randomized Controlled Trial. The Scientific World Journal No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1051511
American Medical Association (AMA)
Ganjali, Shiva& Sahebkar, Amirhossein& Mahdipour, Elahe& Jamialahmadi, Khadijeh& Torabi, Sepideh& Akhlaghi, Saeed…[et al.]. Investigation of the Effects of Curcumin on Serum Cytokines in Obese Individuals: A Randomized Controlled Trial. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1051511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051511