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Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction
Joint Authors
Tančić-Gajić, Milina
Danica, Lisulov Popovic
Krotin, Mirjana
Zdravkovic, Marija
Soldatovic, Ivan
Zdravkovic, Darko
Brajkovic, Milica
Gardijan, Vera
Saric, Jelena
Pokrajac, Ruzica
Lovic, Dragan
Stevanovic, Predrag
Vukcevic, Miodrag
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The aim of the study was to evaluate whether obstructive sleep apnea (OSA) contributes directly to left ventricular (LV) diastolic and regional systolic dysfunction in newly diagnosed OSA with normal left ventricle ejection fraction.
Methods.
125 consecutive patients were prospectively enrolled in the study.
Control group consisted of 78 asymptomatic age-matched healthy subjects who did not have any cardiovascular and respiratory diseases.
All patients had undergone overnight polysomnography and standard transthoracic and tissue Doppler imaging echocardiogram.
Results.
The E/A ratio and the peak E wave at mitral flow were significantly lower and the peak A wave at mitral flow was significantly higher in OSA patients compared with control subjects.
Left ventricle isovolumetric relaxation time (IVRT) and mitral valve flow propagation (MVFP) were significantly longer in OSA patients than in controls.
Tissue Doppler derived S ′ amplitude of lateral part at mitral valve ( S ′ Lm ) and E ′ wave amplitudes both at the lateral ( E ′ Lm ) and septal parts of the mitral valve ( E ′ Sm ) were significantly lower in OSA patients compared to controls.
Conclusion.
Newly diagnosed OSA patients with normal global LV function have significantly impaired diastolic function and regional longitudinal systolic function.
OSA is independently associated with these changes in LV function.
American Psychological Association (APA)
Danica, Lisulov Popovic& Krotin, Mirjana& Zdravkovic, Marija& Soldatovic, Ivan& Zdravkovic, Darko& Brajkovic, Milica…[et al.]. 2014. Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051515
Modern Language Association (MLA)
Danica, Lisulov Popovic…[et al.]. Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1051515
American Medical Association (AMA)
Danica, Lisulov Popovic& Krotin, Mirjana& Zdravkovic, Marija& Soldatovic, Ivan& Zdravkovic, Darko& Brajkovic, Milica…[et al.]. Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051515
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051515