MicroRNA-222 Expression and Its Prognostic Potential in Non-Small Cell Lung Cancer
Joint Authors
Mao, Kai-ping
Zhang, Wei-na
Liang, Xiao-min
Ma, Yu-rong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-13
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Overexpression of miR-222 has been found in several types of cancers; however, the expression of miR-222 in non-small cell lung cancer (NSCLC) and its prognostic values are unclear.
This study aimed to investigate whether the miR-222 expression level is related to clinicopathological factors and prognosis of NSCLC.
Through a prospective study, 100 pairs of NSCLC tissues and adjacent normal tissues were examined by quantitative reverse-transcription polymerase chain reaction.
The correlation between miR-222 expression and clinicopathological features was analyzed, and the significance of miR-222 as a prognostic factor and its relationship with survival were determined.
Results showed that the expression levels of miR-222 were significantly elevated in the NSCLC tissue compared with that in adjacent normal tissue.
In addition, Cox’s proportional hazards model analysis confirmed that miR-222 high expression level was an independent predictor of poor prognosis.
In conclusion, miR-222 overexpression is involved in the poor prognosis of NSCLC and can be used as a biomarker for selection of cases requiring especial attention.
American Psychological Association (APA)
Mao, Kai-ping& Zhang, Wei-na& Liang, Xiao-min& Ma, Yu-rong. 2014. MicroRNA-222 Expression and Its Prognostic Potential in Non-Small Cell Lung Cancer. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1051557
Modern Language Association (MLA)
Mao, Kai-ping…[et al.]. MicroRNA-222 Expression and Its Prognostic Potential in Non-Small Cell Lung Cancer. The Scientific World Journal No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1051557
American Medical Association (AMA)
Mao, Kai-ping& Zhang, Wei-na& Liang, Xiao-min& Ma, Yu-rong. MicroRNA-222 Expression and Its Prognostic Potential in Non-Small Cell Lung Cancer. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1051557
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051557