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Angiogenesis in Spontaneous Tumors and Implications for Comparative Tumor Biology
Joint Authors
Al-Dissi, A.
Chau, C. H.
Oliveira, J. T. de
Figg, William Douglas
Gärtner, Fatima
Sarli, Giuseppe
Benazzi, Cinzia
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-19
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Blood supply is essential for development and growth of tumors and angiogenesis is the fundamental process of new blood vessel formation from preexisting ones.
Angiogenesis is a prognostic indicator for a variety of tumors, and it coincides with increased shedding of neoplastic cells into the circulation and metastasis.
Several molecules such as cell surface receptors, growth factors, and enzymes are involved in this process.
While antiangiogenic therapy for cancer has been proposed over 20 years ago, it has garnered much controversy in recent years within the scientific community.
The complex relationships between the angiogenic signaling cascade and antiangiogenic substances have indicated the angiogenic pathway as a valid target for anticancer drug development and VEGF has become the primary antiangiogenic drug target.
This review discusses the basic and clinical perspectives of angiogenesis highlighting the importance of comparative biology in understanding tumor angiogenesis and the integration of these model systems for future drug development.
American Psychological Association (APA)
Benazzi, Cinzia& Al-Dissi, A.& Chau, C. H.& Figg, William Douglas& Sarli, Giuseppe& Oliveira, J. T. de…[et al.]. 2014. Angiogenesis in Spontaneous Tumors and Implications for Comparative Tumor Biology. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1051605
Modern Language Association (MLA)
Benazzi, Cinzia…[et al.]. Angiogenesis in Spontaneous Tumors and Implications for Comparative Tumor Biology. The Scientific World Journal No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1051605
American Medical Association (AMA)
Benazzi, Cinzia& Al-Dissi, A.& Chau, C. H.& Figg, William Douglas& Sarli, Giuseppe& Oliveira, J. T. de…[et al.]. Angiogenesis in Spontaneous Tumors and Implications for Comparative Tumor Biology. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1051605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051605