Maternal Circulating Concentrations of Tumor Necrosis Factor-Alpha, Leptin, and Adiponectin in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis
Joint Authors
Xu, Jie
Zhao, Yan Hong
Chen, Yun Ping
Yuan, Xiao Lei
Wang, Jiao
Zhu, Hui
Lu, Chun Mei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications.
Inflammation may play a role in the pathogenesis of GDM.
We performed a systematic review and meta-analysis to determine whether maternal serum concentration of tumor necrosis factor-alpha (TNF-α), leptin, and adiponectin were associated with GDM.
A systematic search of PubMed and Medline was undertaken.
In total, 27 trials were evaluated by meta-analyses using the software Review Manager 5.0.
The results showed that maternal TNF-α ( P = 0.0003 ) and leptin ( P < 0.00001 ) concentrations were significantly higher in GDM patients versus controls.
However, maternal adiponectin ( P < 0.00001 ) concentration was significantly lower in GDM patients compared with controls.
Subgroup analysis taking in consideration the effect of obesity on maternal adipokine levels showed that circulating levels of TNF-α and leptin remained elevated in GDM patients compared to their body mass index (BMI) matched controls, and adiponectin level remained depressed in GDM individuals.
Our findings strengthen the clinical evidence that GDM is accompanied by exaggerated inflammatory responses.
American Psychological Association (APA)
Xu, Jie& Zhao, Yan Hong& Chen, Yun Ping& Yuan, Xiao Lei& Wang, Jiao& Zhu, Hui…[et al.]. 2014. Maternal Circulating Concentrations of Tumor Necrosis Factor-Alpha, Leptin, and Adiponectin in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1051631
Modern Language Association (MLA)
Xu, Jie…[et al.]. Maternal Circulating Concentrations of Tumor Necrosis Factor-Alpha, Leptin, and Adiponectin in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis. The Scientific World Journal No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1051631
American Medical Association (AMA)
Xu, Jie& Zhao, Yan Hong& Chen, Yun Ping& Yuan, Xiao Lei& Wang, Jiao& Zhu, Hui…[et al.]. Maternal Circulating Concentrations of Tumor Necrosis Factor-Alpha, Leptin, and Adiponectin in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1051631
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051631