Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine
Joint Authors
Wawryk-Gawda, Ewelina
Chylińska-Wrzos, Patrycja
Lis-Sochocka, Marta
Bulak, Kamila
Jodłowska-Jędrych, Barbara
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Cladribine is a purine nucleoside analog which initiates the apoptotic mechanism within cells.
Moreover, the available data confirms that cladribine, with the participation of the p53 protein, as well as the proapoptotic proteins from the Bcl-2 family, also induces the activation of the intrinsic apoptosis pathway.
However, while there has been a lot of research devoted to the effect of cladribine on lymphatic system cells, little is known about the impact of cladribine on the reproductive system.
The aim of our study was to evaluate apoptosis in oviduct epithelial cells sourced from 15 different female rats.
In so doing, the sections were stained with caspases 3, 9, and 8.
Results suggest that cladribine also induces apoptosis in the oviduct epithelial cells by way of the intrinsic pathway.
Indeed, the discontinuing of the administration of cladribine leads to a reduction in the amount of apoptotic cells in the oviduct epithelium.
American Psychological Association (APA)
Wawryk-Gawda, Ewelina& Chylińska-Wrzos, Patrycja& Lis-Sochocka, Marta& Bulak, Kamila& Jodłowska-Jędrych, Barbara. 2014. Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1051634
Modern Language Association (MLA)
Wawryk-Gawda, Ewelina…[et al.]. Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1051634
American Medical Association (AMA)
Wawryk-Gawda, Ewelina& Chylińska-Wrzos, Patrycja& Lis-Sochocka, Marta& Bulak, Kamila& Jodłowska-Jędrych, Barbara. Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1051634
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051634