High Association between Human Circulating MicroRNA-497 and Acute Myocardial Infarction

Abstract EN

Recent papers have reported the fundamental roles of miR-497 in infarction which acute myocardial infarction (AMI) belongs to.

However, the expression levels of miR-497 in AMI patients were unclear, especially the circulating miR-497 that was detectable in the human plasma.

In this study, we focused on the expression levels of circulating miR-497 in AMI and the roles of plasma miR-497 as a promising biomarker for AMI.

The plasma miR-497 levels were detected from 27 AMI patients and 31 healthy volunteers by qRT-PCR.

The cTnI concentrations of these samples were also analyzed by ELISA.

Results showed circulating miR-497 levels were upregulated in AMI patients at 4 h, 8 h, 12 h, and 24 h, by contrast to those in control.

Interestingly, time courses of circulating miR-497 levels displayed similar trends to that of cTnI concentrations in AMI patients; further study revealed the high correlation between circulating miR-497 and cTnI concentrations (r=0.573, P<0.001).

At last, the receiver operating characteristic (ROC) curve was performed and declared that there was a faithworthy sensitivity and specificity to identify the AMI patients by using circulating miR-497.

In conclusion, circulating miR-497 might be a promising biomarker for AMI identification and there was high association between human miR-497 and acute myocardial infarction.