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Effect of Preventive Hormonal Therapy on Breast Density: A Systematic Qualitative Review
Joint Authors
Lienart, Virginie
Carly, Birgit
Kang, Xin
Guzy, Laura
Sajovitz, Anna-Maria
Liebens, Fabienne
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-27
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Breast density (BD) is recognized as one of the strongest independent risk factors of breast cancer (BC).
Unlike most other risk factors, BD can be modified, suggesting that it may be a biomarker for preventive interventions.
We conducted a qualitative systematic review to address the effect of preventive hormonal therapy on BD.
Among the 26 relevant studies, 10 assessed the effect of tamoxifen on BD (TAM: n = 2 877 ), 9 that of raloxifene (RLX: n = 1 544 ), and 7 that of aromatase inhibitors (AI: n = 416 ).
The studies were characterized by a large heterogeneity in designs and in methods of BD measurement.
BD could be reduced by TAM (10 studies/10).
However, the effect of RLX and AI on BD remains unclear due to conflicting results between studies.
Consequently, it is crucial to develop practical, accurate, and reproducible methods of measurement in order to be able to compare the effect of preventive hormonal agents on BD and to determine whether change in BD can be used as a predictor of response to therapy.
American Psychological Association (APA)
Lienart, Virginie& Carly, Birgit& Kang, Xin& Guzy, Laura& Sajovitz, Anna-Maria& Liebens, Fabienne. 2014. Effect of Preventive Hormonal Therapy on Breast Density: A Systematic Qualitative Review. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-24.
https://search.emarefa.net/detail/BIM-1051687
Modern Language Association (MLA)
Lienart, Virginie…[et al.]. Effect of Preventive Hormonal Therapy on Breast Density: A Systematic Qualitative Review. The Scientific World Journal No. 2014 (2014), pp.1-24.
https://search.emarefa.net/detail/BIM-1051687
American Medical Association (AMA)
Lienart, Virginie& Carly, Birgit& Kang, Xin& Guzy, Laura& Sajovitz, Anna-Maria& Liebens, Fabienne. Effect of Preventive Hormonal Therapy on Breast Density: A Systematic Qualitative Review. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-24.
https://search.emarefa.net/detail/BIM-1051687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051687