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High-Dose Amoxicillin with Clavulanate for the Treatment of Acute Otitis Media in Children
Joint Authors
Shiao, An-Suey
Tu, Tzong-Yang
Chu, Chia-Huei
Wang, Mao-Che
Lin, Liang-Yu
Huang, Chii-Yuan
Liao, Wen-Huei
Ho, Ching-Yin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Objective.
This study uses the acute otitis media clinical practice guideline proposed in 2004 as a reference to evaluate whether antibiotics doses that are in line with the recommendations lead to better prognosis.
The study also attempts to clarify possible factors that influence the outcome.
Study Design.
Retrospective cohort study.
Subjects and Methods.
A total of 400 children with acute otitis media were enrolled.
The dosage of amoxicillin was considered to be appropriate when in accord with clinical practice guidelines, that is, 80–90 mg/kg/day.
The outcome was defined according to the description of tympanic membrane on medical records.
Multivariate logistic regression was used to analyze the relationship between antibiotic dosage and prognosis after adjusting for baseline factors.
Results.
The majority of prescriptions were under dosage (89.1%) but it was not noticeably associated with outcome (P= 0.41).
The correlation between under dosage and poor prognosis was significant in children below 20 kg with bilateral acute otitis media (odds ratio 1.63; 95% CI 1.02–2.59, P=0.04).
Conclusion.
Treating acute otitis media in children, high-dose amoxicillin with clavulanate as recommended in the clinical practice guideline was superior to conventional doses only in children under 20 kg with bilateral diseases.
American Psychological Association (APA)
Chu, Chia-Huei& Wang, Mao-Che& Lin, Liang-Yu& Tu, Tzong-Yang& Huang, Chii-Yuan& Liao, Wen-Huei…[et al.]. 2014. High-Dose Amoxicillin with Clavulanate for the Treatment of Acute Otitis Media in Children. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1051784
Modern Language Association (MLA)
Chu, Chia-Huei…[et al.]. High-Dose Amoxicillin with Clavulanate for the Treatment of Acute Otitis Media in Children. The Scientific World Journal No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1051784
American Medical Association (AMA)
Chu, Chia-Huei& Wang, Mao-Che& Lin, Liang-Yu& Tu, Tzong-Yang& Huang, Chii-Yuan& Liao, Wen-Huei…[et al.]. High-Dose Amoxicillin with Clavulanate for the Treatment of Acute Otitis Media in Children. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1051784
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051784