Identification of Family Specific Fingerprints in β-Lactamase Families
Joint Authors
Srivastava, Abhishikha
Singhal, Neelja
Goel, Manisha
Virdi, Jugsharan Singh
Kumar, Manish
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Beta-lactamases are a superfamily of enzymes which degrade the β-lactam class of antibiotics.
They are produced endogenously by the bacterial cells, which when exposed to the β-lactam class of antibiotics inactivate them by cleaving the β-lactam ring.
Based on the presence or absence of metallic ligand, β-lactamases have been divided into two broad functional classes.
β-Lactamases are a constitutively evolving and expanding superfamily of enzymes, which could be further subdivided on the basis of presence/absence of conserved motifs.
In the present study we have used the MEME/MAST suit to identify the patterns/motifs which are specific to a particular family or subfamily of β-lactamases.
The family specific patterns/motifs can be also useful in recognizing and assigning newly discovered β-lactamases to one or the other family or subfamily.
Cross-validation showed that the proposed method is highly sensitive and specific.
We have also designed a webserver, LactFP, for this purpose.
American Psychological Association (APA)
Srivastava, Abhishikha& Singhal, Neelja& Goel, Manisha& Virdi, Jugsharan Singh& Kumar, Manish. 2014. Identification of Family Specific Fingerprints in β-Lactamase Families. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051853
Modern Language Association (MLA)
Srivastava, Abhishikha…[et al.]. Identification of Family Specific Fingerprints in β-Lactamase Families. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1051853
American Medical Association (AMA)
Srivastava, Abhishikha& Singhal, Neelja& Goel, Manisha& Virdi, Jugsharan Singh& Kumar, Manish. Identification of Family Specific Fingerprints in β-Lactamase Families. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051853