Effect of GABAB Receptor Antagonist (CGP35348) on Learning and Memory in Albino Mice
Joint Authors
Iqbal, F.
Ali, M.
Iqbal, Shahid
Akbar, Atif
Arfa, Fatima
Khakwani, Saba
Ullah, Asmat
Gillani, Q.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The present study was designed to demonstrate the potential effect of CGP 35348 (GABAB receptor antagonist) on the learning, memory formation, and neuromuscular coordination in albino mouse.
Mice were intrapertoneally injected with 1 mg CGP 35348/mL of distilled water/Kg body weight, while the control animals were injected with equal volume of saline solution.
A battery of neurological tests was applied following the intrapertoneal injections.
Results of rota rod indicated that CGP 35348 had no effect on neuromuscular coordination in both male (P=0.528) and female (P=0.125) albino mice.
CGP 35348 treated females demonstrated poor exploratory behavior during open filed for several parameters (time mobile (P=0.04), time immobile (P=0.04), rotations (P=0.04), and anticlockwise rotations (P=0.038)).
The results for Morris water maze (MWM) retention phase indicated that CGP 35348 treated male mice took shorter latency to reach the hidden platform (P=0.04) than control indicating improved memory.
This observation was complemented by the swim strategies used by mice during training days in MWM as CGP 35348 treated males used more direct and focal approach to reach the platform as the training proceeded.
American Psychological Association (APA)
Gillani, Q.& Iqbal, Shahid& Arfa, Fatima& Khakwani, Saba& Akbar, Atif& Ullah, Asmat…[et al.]. 2014. Effect of GABAB Receptor Antagonist (CGP35348) on Learning and Memory in Albino Mice. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1051866
Modern Language Association (MLA)
Gillani, Q.…[et al.]. Effect of GABAB Receptor Antagonist (CGP35348) on Learning and Memory in Albino Mice. The Scientific World Journal No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1051866
American Medical Association (AMA)
Gillani, Q.& Iqbal, Shahid& Arfa, Fatima& Khakwani, Saba& Akbar, Atif& Ullah, Asmat…[et al.]. Effect of GABAB Receptor Antagonist (CGP35348) on Learning and Memory in Albino Mice. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1051866
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051866