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Gossypol Promotes Degeneration of Ovarian Follicles in Rats
Joint Authors
Soto-Blanco, Benito
Gadelha, Ivana Cristina N.
Oloris, Silvia Catarina S.
Melo, Marília M.
Fernandes de Macedo, Michelly
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The present study aimed to determine if gossypol interferes with ovarian follicles in rats.
Twenty-four female Wistar rats were assigned to two equal groups: one control group and the other dosed with gossypol (25 mg/kg/day, subcutaneously) for 15 days.
Ovarian follicles were histologically classified according to the stage of development and as normal or atretic.
Gossypol treatment reduced the length of estrous with an increase in the duration of the diestrus phase.
This compound was responsible for reduced serum levels of T4 and progesterone.
Treatment with gossypol was responsible for a significant reduction in the number of normal ovarian follicles and a significant increase in the number of atretic follicles, both in all stages of development.
Thus, treatment of rats with gossypol was responsible for reduction in the number of viable follicles and changes in hormone levels that resulted in interference of the estrous cycle.
American Psychological Association (APA)
Gadelha, Ivana Cristina N.& Fernandes de Macedo, Michelly& Oloris, Silvia Catarina S.& Melo, Marília M.& Soto-Blanco, Benito. 2014. Gossypol Promotes Degeneration of Ovarian Follicles in Rats. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051877
Modern Language Association (MLA)
Gadelha, Ivana Cristina N.…[et al.]. Gossypol Promotes Degeneration of Ovarian Follicles in Rats. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1051877
American Medical Association (AMA)
Gadelha, Ivana Cristina N.& Fernandes de Macedo, Michelly& Oloris, Silvia Catarina S.& Melo, Marília M.& Soto-Blanco, Benito. Gossypol Promotes Degeneration of Ovarian Follicles in Rats. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051877
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051877