Evaluation of the Cerebral State Index in Cats under Isoflurane Anaesthesia: Dose-Effect Relationship and Prediction of Clinical Signs
Joint Authors
Sousa, Joana R.
Ribeiro, Lénio
Silva, Aura
Ferreira, David A.
Source
Veterinary Medicine International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The performance of the cerebral state index (CSI) in reflecting different levels of isoflurane anaesthesia was evaluated in ten cats subjected to four end-tidal isoflurane concentrations (EtIso), each maintained for 15 minutes (0.8%, 1.2%, 1.6%, or 2.0% EtIso).
The CSI, hemodynamic data, ocular reflexes, and eye position were recorded for each EtIso concentration.
Pharmacodynamic analysis of CSI with EtIso was performed, as well as prediction probability analysis with a clinical scale based on the eye reflexes.
The CSI values showed great variability.
Between all parameters, burst suppression ratio showed the better fitting with the sigmoidal concentration-effect model ( R 2 = 0.93 ) followed by CSI ( R 2 = 0.82 ) and electromyographic activity ( R 2 = 0.79 ).
EtIso was the variable with better prediction of the clinical scale of anaesthesia (prediction probability value of 0.94).
Although the CSI values decrease with increasing isoflurane concentrations, the huge variability in CSI values may be a strong limitation for its use in cats and it seems to be no better than EtIso as a predictor of clinical signs.
American Psychological Association (APA)
Sousa, Joana R.& Ribeiro, Lénio& Silva, Aura& Ferreira, David A.. 2014. Evaluation of the Cerebral State Index in Cats under Isoflurane Anaesthesia: Dose-Effect Relationship and Prediction of Clinical Signs. Veterinary Medicine International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051922
Modern Language Association (MLA)
Sousa, Joana R.…[et al.]. Evaluation of the Cerebral State Index in Cats under Isoflurane Anaesthesia: Dose-Effect Relationship and Prediction of Clinical Signs. Veterinary Medicine International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1051922
American Medical Association (AMA)
Sousa, Joana R.& Ribeiro, Lénio& Silva, Aura& Ferreira, David A.. Evaluation of the Cerebral State Index in Cats under Isoflurane Anaesthesia: Dose-Effect Relationship and Prediction of Clinical Signs. Veterinary Medicine International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051922
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051922