Comparative Pharmacokinetics of Levofloxacin in Healthy and Renal Damaged Muscovy Ducks following Intravenous and Oral Administration
Joint Authors
Soliman, Ahmed
Aboubakr, Mohamed
Source
Veterinary Medicine International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The pharmacokinetics aspects of levofloxacin were studied in healthy and experimentally renal damaged Muscovy ducks after single intravenous (IV) and oral (PO) dose of 10 mg kg−1 bwt.
Following IV administration, elimination half-life (t 1/2(β)) and mean residence time (MRT) were longer in renal damaged ducks than in healthy ones.
Total clearance ( C l t o t ) in renal damaged ducks (0.20 L kg−1 h−1) was significantly lower as compared to that in healthy ones (0.41 L kg−1 h−1).
Following PO administration, the peak serum concentration ( C m a x ) was higher in renal damaged than in healthy ducks and was achieved at maximum time ( t m a x ) of 2.47 and 2.05 h, respectively.
The drug was eliminated ( t 1 / 2 ( e l ) ) at a significant slower rate (3.94 h) in renal damaged than in healthy ducks (2.89 h).
The pharmacokinetic profile of levofloxacin is altered in renal damaged ducks due to the increased serum levofloxacin concentrations compared with that in clinically healthy ducks.
Oral administration of levofloxacin at 10 mg kg−1 bwt may be highly efficacious against susceptible bacteria in ducks.
Also, the dose of levofloxacin should be reduced in renal damaged ducks.
Pharmacokinetic/pharmacodynamic integration revealed significantly higher values for C m a x /MIC and AUC/MIC ratios in renal damaged ducks than in healthy ones, indicating the excellent pharmacokinetic characteristics of levofloxacin in renal damaged ducks.
American Psychological Association (APA)
Aboubakr, Mohamed& Soliman, Ahmed. 2014. Comparative Pharmacokinetics of Levofloxacin in Healthy and Renal Damaged Muscovy Ducks following Intravenous and Oral Administration. Veterinary Medicine International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1051956
Modern Language Association (MLA)
Aboubakr, Mohamed& Soliman, Ahmed. Comparative Pharmacokinetics of Levofloxacin in Healthy and Renal Damaged Muscovy Ducks following Intravenous and Oral Administration. Veterinary Medicine International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1051956
American Medical Association (AMA)
Aboubakr, Mohamed& Soliman, Ahmed. Comparative Pharmacokinetics of Levofloxacin in Healthy and Renal Damaged Muscovy Ducks following Intravenous and Oral Administration. Veterinary Medicine International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1051956
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051956