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Epstein-Barr Virus Association with Peptic Ulcer Disease
Joint Authors
Cárdenas-Mondragón, María G.
Torres, Javier
Flores-Luna, Lourdes
Carreón-Talavera, Ricardo
Camorlinga-Ponce, Margarita
Fuentes-Pananá, Ezequiel M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Helicobacter pylori (HP) infection and nonsteroidal anti-inflammatory drugs (NSAID) use are considered the main risk to develop peptic ulcer disease (PUD).
However, PUD also occurs in the absence of HP infection and/or NSAID use.
Recently, we have found evidence that Epstein-Barr virus (EBV) reactivation increases the risk to develop premalignant and malignant gastric lesions.
Objective.
To study a possible association between EBV and PUD.
Methods.
Antibodies against an EBV reactivation antigen, HP, and the HP virulence factor CagA were measured in sera from 207 Mexican subjects, controls (healthy individuals, n = 129), and PUD patients (n = 78, 58 duodenal and 20 gastric ulcers).
Statistical associations were estimated.
Results.
Duodenal PUD was significantly associated with high anti-EBV IgG titers (p = 0.022, OR = 2.5), while anti-EBV IgA was positively associated with gastric PUD (p = 0.002, OR = 10.1).
Conclusions.
Our study suggests that EBV reactivation in gastric and duodenal epithelium increases the risk to develop PUD.
American Psychological Association (APA)
Cárdenas-Mondragón, María G.& Torres, Javier& Flores-Luna, Lourdes& Carreón-Talavera, Ricardo& Camorlinga-Ponce, Margarita& Fuentes-Pananá, Ezequiel M.. 2015. Epstein-Barr Virus Association with Peptic Ulcer Disease. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1052341
Modern Language Association (MLA)
Cárdenas-Mondragón, María G.…[et al.]. Epstein-Barr Virus Association with Peptic Ulcer Disease. Analytical Cellular Pathology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1052341
American Medical Association (AMA)
Cárdenas-Mondragón, María G.& Torres, Javier& Flores-Luna, Lourdes& Carreón-Talavera, Ricardo& Camorlinga-Ponce, Margarita& Fuentes-Pananá, Ezequiel M.. Epstein-Barr Virus Association with Peptic Ulcer Disease. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1052341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052341