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Use of miRNAs as Biomarkers in Sepsis
Joint Authors
Dumache, Raluca
Rogobete, Alexandru Florin
Bedreag, Ovidiu Horea
Sarandan, Mirela
Cradigati, Alina Carmen
Papurica, Marius
Dumbuleu, Corina Maria
Nartita, Radu
Sandesc, Dorel
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Sepsis is one of the most common causes of death in critical patients.
Severe generalized inflammation, infections, and severe physiological imbalances significantly decrease the survival rate with more than 50%.
Moreover, monitoring, evaluation, and therapy management often become extremely difficult for the clinician in this type of patients.
Current methods of diagnosing sepsis vary based especially on the determination of biochemical-humoral markers, such as cytokines, components of the complement, and proinflammatory and anti-inflammatory compounds.
Recent studies highlight the use of new biomarkers for sepsis, namely, miRNAs.
miRNAs belong to a class of small, noncoding RNAs with an approximate content of 19–23 nucleotides.
Following biochemical and physiological imbalances, the expression of miRNAs in blood or other body fluids changes significantly.
Moreover, its stability, specificity, and selectivity make miRNAs ideal candidates for sepsis biomarkers.
In conclusion, we can affirm that stable species of circulating miRNAs represent potential biomarkers for monitoring the evolution of sepsis.
American Psychological Association (APA)
Dumache, Raluca& Rogobete, Alexandru Florin& Bedreag, Ovidiu Horea& Sarandan, Mirela& Cradigati, Alina Carmen& Papurica, Marius…[et al.]. 2015. Use of miRNAs as Biomarkers in Sepsis. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1052342
Modern Language Association (MLA)
Dumache, Raluca…[et al.]. Use of miRNAs as Biomarkers in Sepsis. Analytical Cellular Pathology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1052342
American Medical Association (AMA)
Dumache, Raluca& Rogobete, Alexandru Florin& Bedreag, Ovidiu Horea& Sarandan, Mirela& Cradigati, Alina Carmen& Papurica, Marius…[et al.]. Use of miRNAs as Biomarkers in Sepsis. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1052342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052342