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Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation
Joint Authors
Zupkó, István
Danciu, Corina
Soica, Codruta
Dehelean, Cristina
Pinzaru, Iulia
Csányi, Erzsébet
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study focuses on the synthesis and analysis of a genistein ester derivative with myristic acid followed by beta cyclodextrin encapsulation; physicochemical analysis using consecrated techniques such as FTIR, MS, DSC, and SEM revealed both a successful esterification and inclusion inside the cyclodextrin cavity.
Cytotoxic effects were measured in vitro on three human cell lines: HeLa (cervix adenocarcinoma), A2780 (ovary carcinoma), and A431 (skin epidermoid carcinoma).
The in vitro biological analysis exhibited rather poor antiproliferative results on all three tested cancer cell lines, behavior that may be due to the high stability of the complex within the in vitro environment.
American Psychological Association (APA)
Danciu, Corina& Soica, Codruta& Dehelean, Cristina& Zupkó, István& Csányi, Erzsébet& Pinzaru, Iulia. 2015. Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1052346
Modern Language Association (MLA)
Danciu, Corina…[et al.]. Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation. Analytical Cellular Pathology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1052346
American Medical Association (AMA)
Danciu, Corina& Soica, Codruta& Dehelean, Cristina& Zupkó, István& Csányi, Erzsébet& Pinzaru, Iulia. Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1052346
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052346