The Role of “Bone Immunological Niche” for a New Pathogenetic Paradigm of Osteoporosis
Joint Authors
Cianci, Rossella
Cianci, R.
Ciro Tamburrelli, Francesco
Zirio, Gianfranco
Newton, Estelle E.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue.
The etiology and pathogenetic mechanisms of osteoporosis have not been clearly elucidated.
Osteoporosis is linked to bone resorption by the activation of the osteoclastogenic process.
The breakdown of homeostasis among pro- and antiosteoclastogenic cells causes unbalanced bone remodeling.
The complex interactions among these cells in the bone microenvironment involve several mediators and proinflammatory pathways.
Thus, we may consider the bone microenvironment as a complex system in which local and systemic immunity are regulated and we propose to consider it as an “immunological niche.” The study of the “bone immunological niche” will permit a better understanding of the complex cell trafficking which regulates bone resorption and disease.
The goal of a perfect therapy for osteoporosis would be to potentiate good cells and block the bad ones.
In this scenario, additional factors may take part in helping or hindering the proosteoblastogenic factors.
Several proosteoblastogenic and antiosteoclastogenic agents have already been identified and some have been developed and commercialized as biological therapies for osteoporosis.
Targeting the cellular network of the “bone immunological niche” may represent a successful strategy to better understand and treat osteoporosis and its complications.
American Psychological Association (APA)
Cianci, Rossella& Ciro Tamburrelli, Francesco& Zirio, Gianfranco& Newton, Estelle E.& Cianci, R.. 2015. The Role of “Bone Immunological Niche” for a New Pathogenetic Paradigm of Osteoporosis. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1052356
Modern Language Association (MLA)
Cianci, Rossella…[et al.]. The Role of “Bone Immunological Niche” for a New Pathogenetic Paradigm of Osteoporosis. Analytical Cellular Pathology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1052356
American Medical Association (AMA)
Cianci, Rossella& Ciro Tamburrelli, Francesco& Zirio, Gianfranco& Newton, Estelle E.& Cianci, R.. The Role of “Bone Immunological Niche” for a New Pathogenetic Paradigm of Osteoporosis. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1052356
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052356