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Stabilizing versus Destabilizing the Microtubules: A Double-Edge Sword for an Effective Cancer Treatment Option?
Joint Authors
Fanale, Daniele
Bazan, Viviana
Castiglia, Marta
Bronte, Giuseppe
Cicero, Giuseppe
Passiglia, Francesco
Calò, Valentina
Di Piazza, Florinda
Barraco, Nadia
Cangemi, Antonina
Catarella, Maria Teresa
Insalaco, Lavinia
Listì, Angela
Maragliano, Rossella
Massihnia, Daniela
Perez, Alessandro
Toia, Francesca
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-21
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Microtubules are dynamic and structural cellular components involved in several cell functions, including cell shape, motility, and intracellular trafficking.
In proliferating cells, they are essential components in the division process through the formation of the mitotic spindle.
As a result of these functions, tubulin and microtubules are targets for anticancer agents.
Microtubule-targeting agents can be divided into two groups: microtubule-stabilizing, and microtubule-destabilizing agents.
The former bind to the tubulin polymer and stabilize microtubules, while the latter bind to the tubulin dimers and destabilize microtubules.
Alteration of tubulin-microtubule equilibrium determines the disruption of the mitotic spindle, halting the cell cycle at the metaphase-anaphase transition and, eventually, resulting in cell death.
Clinical application of earlier microtubule inhibitors, however, unfortunately showed several limits, such as neurological and bone marrow toxicity and the emergence of drug-resistant tumor cells.
Here we review several natural and synthetic microtubule-targeting agents, which showed antitumor activity and increased efficacy in comparison to traditional drugs in various preclinical and clinical studies.
Cryptophycins, combretastatins, ombrabulin, soblidotin, D-24851, epothilones and discodermolide were used in clinical trials.
Some of them showed antiangiogenic and antivascular activity and others showed the ability to overcome multidrug resistance, supporting their possible use in chemotherapy.
American Psychological Association (APA)
Fanale, Daniele& Bronte, Giuseppe& Passiglia, Francesco& Calò, Valentina& Castiglia, Marta& Di Piazza, Florinda…[et al.]. 2015. Stabilizing versus Destabilizing the Microtubules: A Double-Edge Sword for an Effective Cancer Treatment Option?. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1052364
Modern Language Association (MLA)
Fanale, Daniele…[et al.]. Stabilizing versus Destabilizing the Microtubules: A Double-Edge Sword for an Effective Cancer Treatment Option?. Analytical Cellular Pathology No. 2015 (2015), pp.1-19.
https://search.emarefa.net/detail/BIM-1052364
American Medical Association (AMA)
Fanale, Daniele& Bronte, Giuseppe& Passiglia, Francesco& Calò, Valentina& Castiglia, Marta& Di Piazza, Florinda…[et al.]. Stabilizing versus Destabilizing the Microtubules: A Double-Edge Sword for an Effective Cancer Treatment Option?. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1052364
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052364