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Limitations on the Detection Rate of High-Risk HPV by Hybrid Capture 2 Methodology in High Grade Intraepithelial (HSIL) or Atypical Squamous Cells-Cannot Exclude HSIL (ASC-H) Cytological Lesions with Proved CIN2+
Joint Authors
Simon, Philippe
Noël, Jean-Christophe
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-02
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Recent literature data suggest that the high-risk human papillomaviruses (HR-HPVs) testing with several molecular techniques could be an alternative to cytology in the detection of cervical intraepithelial neoplasias of grade 2 or worse (CIN2+).
However, any molecular techniques have its own limits and may give false negative results which must be clearly known before undertaking a primary HPV screening.
This study aims to evaluate the performance of the high-risk HPV hybrid capture II detection kit (HCII) which is considered as a “gold standard technique” in a series of 100 women having proved both cytological lesions of atypical squamous cells-cannot exclude an HSIL (ASC-H) or high-grade squamous intraepithelial lesion (HSIL) and histological lesions of CIN2+.
The clinical sensitivity of HCII in women with a cytological diagnosis of ASC-H/HSIL and a diagnosis of CIN2+ is high but not absolute and estimated at 96% (95,6% and 100% of women with a diagnosis of CIN2/3 or invasive squamous cell carcinoma, resp.).
These data although they are infrequent must be clearly referred before to start an HPV primary screening of CIN2+ especially with HCII methodology.
American Psychological Association (APA)
Noël, Jean-Christophe& Simon, Philippe. 2015. Limitations on the Detection Rate of High-Risk HPV by Hybrid Capture 2 Methodology in High Grade Intraepithelial (HSIL) or Atypical Squamous Cells-Cannot Exclude HSIL (ASC-H) Cytological Lesions with Proved CIN2+. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1052367
Modern Language Association (MLA)
Noël, Jean-Christophe& Simon, Philippe. Limitations on the Detection Rate of High-Risk HPV by Hybrid Capture 2 Methodology in High Grade Intraepithelial (HSIL) or Atypical Squamous Cells-Cannot Exclude HSIL (ASC-H) Cytological Lesions with Proved CIN2+. Analytical Cellular Pathology No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1052367
American Medical Association (AMA)
Noël, Jean-Christophe& Simon, Philippe. Limitations on the Detection Rate of High-Risk HPV by Hybrid Capture 2 Methodology in High Grade Intraepithelial (HSIL) or Atypical Squamous Cells-Cannot Exclude HSIL (ASC-H) Cytological Lesions with Proved CIN2+. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1052367
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052367