Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease
Joint Authors
Filippelli, Amelia
Conti, V.
Manzo, V.
Vatrella, Alessandro
Pelaia, Girolamo
Corbi, Graziamaria
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Chronic Obstructive Pulmonary disease (COPD) is an inflammatory syndrome that represents an increasing health problem, especially in the elderly population.
Drug therapies are symptomatic and inadequate to contrast disease progression and mortality.
Thus, there is an urgent need to clarify the molecular mechanisms responsible for this condition in order to identify new biomarkers and therapeutic targets.
Processes including oxidant/antioxidant, protease/antiprotease, and proliferative/antiproliferative balance and control of inflammatory response become dysfunctional during aging as well as in COPD.
Recently it was suggested that Sirtuin 1 (SIRT1), an antiaging molecule involved in the response to oxidative stress and chronic inflammation, is implicated in both development and progression of COPD.
The present review focuses on the involvement of SIRT1 in the regulation of redox state, inflammation, and premature senescence, all crucial characteristics of COPD phenotypes.
Recent evidence corroborating the statement of the “aging theory for COPD” was also discussed.
American Psychological Association (APA)
Conti, V.& Corbi, Graziamaria& Manzo, V.& Pelaia, Girolamo& Filippelli, Amelia& Vatrella, Alessandro. 2015. Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1052372
Modern Language Association (MLA)
Conti, V.…[et al.]. Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease. Analytical Cellular Pathology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1052372
American Medical Association (AMA)
Conti, V.& Corbi, Graziamaria& Manzo, V.& Pelaia, Girolamo& Filippelli, Amelia& Vatrella, Alessandro. Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1052372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052372