![](/images/graphics-bg.png)
The Attenuated Live Yellow Fever Virus 17D Infects the Thymus and Induces Thymic Transcriptional Modifications of Immunomodulatory Genes in C57BL6 and BALBC Mice
Joint Authors
da Fonseca, Benedito Antônio Lopes
Melo-Lima, Breno Luiz
Moreau, Philippe
Espósito, Danillo Lucas Alves
Figueiredo, Luiz Tadeu Moraes
Donadi, Eduardo Antônio
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Thymus is involved in induction of self-tolerance in T lymphocytes, particularly due to Aire activity.
In peripheral tissues, Treg cells and immunomodulatory molecules, like the major histocompatibility complex (MHC) class Ib molecules, are essential for maintenance of autotolerance during immune responses.
Viral infections can trigger autoimmunity and modify thymic function, and YFV17D immunization has been associated with the onset of autoimmunity, being contraindicated in patients with thymic disorders.
Aiming to study the influence of YFV17D immunization on the transcriptional profiles of immunomodulatory genes in thymus, we evaluated the gene expression of AIRE, FOXP3, H2-Q7 (Qa-2/HLA-G), H2-T23 (Qa-1/HLA-E), H2-Q10, and H2-K1 following immunization with 10,000 LD50 of YFV17D in C57BL/6 and BALB/c mice.
The YFV17D virus replicated in thymus and induced the expression of H2-Q7 (Qa-2/HLA-G) and H2-T23 (Qa-1/HLA-E) transcripts and repressed the expression of AIRE and FOXP3.
Transcriptional expression varied according to tissue and mouse strain analyzed.
Expression of H2-T23 (Qa-1/HLA-E) and FOXP3 was induced in thymus and liver of C57BL/6 mice, which exhibited defective control of viral load, suggesting a higher susceptibility to YFV17D infection.
Since the immunization with YFV17D modulated thymus gene expression in genetically predisposed individuals, the vaccine may be related to the onset of autoimmunity disorders.
American Psychological Association (APA)
Melo-Lima, Breno Luiz& Espósito, Danillo Lucas Alves& da Fonseca, Benedito Antônio Lopes& Figueiredo, Luiz Tadeu Moraes& Moreau, Philippe& Donadi, Eduardo Antônio. 2015. The Attenuated Live Yellow Fever Virus 17D Infects the Thymus and Induces Thymic Transcriptional Modifications of Immunomodulatory Genes in C57BL6 and BALBC Mice. Autoimmune Diseases،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1052387
Modern Language Association (MLA)
Melo-Lima, Breno Luiz…[et al.]. The Attenuated Live Yellow Fever Virus 17D Infects the Thymus and Induces Thymic Transcriptional Modifications of Immunomodulatory Genes in C57BL6 and BALBC Mice. Autoimmune Diseases No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1052387
American Medical Association (AMA)
Melo-Lima, Breno Luiz& Espósito, Danillo Lucas Alves& da Fonseca, Benedito Antônio Lopes& Figueiredo, Luiz Tadeu Moraes& Moreau, Philippe& Donadi, Eduardo Antônio. The Attenuated Live Yellow Fever Virus 17D Infects the Thymus and Induces Thymic Transcriptional Modifications of Immunomodulatory Genes in C57BL6 and BALBC Mice. Autoimmune Diseases. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1052387
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052387