Protein Kinase CK2: A Targetable BCR-ABL Partner in Philadelphia Positive Leukemias
Joint Authors
Morotti, Alessandro
Carrà, Giovanna
Panuzzo, Cristina
Crivellaro, Sabrina
Taulli, Riccardo
Saglio, Giuseppe G.
Guerrasio, Angelo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
BCR-ABL-mediated leukemias, either Chronic Myeloid Leukemia (CML) or Philadelphia positive Acute Lymphoblastic Leukemia (ALL), are the paradigm of targeted molecular therapy of cancer due to the impressive clinical responses obtained with BCR-ABL specific tyrosine kinase inhibitors (TKIs).
However, BCR-ABL TKIs do not allow completely eradicating both CML and ALL.
Furthermore, ALL therapy is associated with much worse responses to TKIs than those observed in CML.
The identification of additional pathways that mediate BCR-ABL leukemogenesis is indeed mandatory to achieve synthetic lethality together with TKI.
Here, we review the role of BCR-ABL/protein kinase CK2 interaction in BCR-ABL leukemias, with potentially relevant implications for therapy.
American Psychological Association (APA)
Morotti, Alessandro& Carrà, Giovanna& Panuzzo, Cristina& Crivellaro, Sabrina& Taulli, Riccardo& Guerrasio, Angelo…[et al.]. 2015. Protein Kinase CK2: A Targetable BCR-ABL Partner in Philadelphia Positive Leukemias. Advances in Hematology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1052445
Modern Language Association (MLA)
Morotti, Alessandro…[et al.]. Protein Kinase CK2: A Targetable BCR-ABL Partner in Philadelphia Positive Leukemias. Advances in Hematology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1052445
American Medical Association (AMA)
Morotti, Alessandro& Carrà, Giovanna& Panuzzo, Cristina& Crivellaro, Sabrina& Taulli, Riccardo& Guerrasio, Angelo…[et al.]. Protein Kinase CK2: A Targetable BCR-ABL Partner in Philadelphia Positive Leukemias. Advances in Hematology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1052445
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052445