Real-World Assessment of Clinical Outcomes in Patients with Lower-Risk Myelofibrosis Receiving Treatment with Ruxolitinib
Joint Authors
Davis, Keith L.
Côté, Isabelle
Kaye, James A.
Mendelson, Estella
Gao, Haitao
Perez Ronco, Julian
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Few trial-based assessments of ruxolitinib in patients with lower-risk myelofibrosis (MF) have been conducted, and no studies have made such assessments in a real-world population.
We assessed changes in spleen size and constitutional symptoms during ruxolitinib treatment using a retrospective, observational review of anonymized US medical record data of patients diagnosed with IPSS low-risk (n=25) or intermediate-1-risk (n=83) MF.
The majority of patients were male (low risk, 60%; intermediate-1 risk, 69%).
Most patients (92% and 77%) were still receiving ruxolitinib at the medical record abstraction date (median observation/exposure time, 8 months).
The proportion of patients with moderate or severe palpable splenomegaly (≥10 cm) decreased from diagnosis (56%) to best response (12%).
Fatigue was reported in 47% of patients and was the most common constitutional symptom.
For most symptoms in both risk groups, shifts in the distribution of severity from more to less severe from diagnosis to best response were observed.
Both patients with low-risk and intermediate-1-risk MF experienced a substantial decrease in spleen size with ruxolitinib treatment in real-world settings.
For most symptoms examined, there were distinct improvements in the distribution of severity during ruxolitinib treatment.
These findings suggest that patients with lower-risk MF may benefit clinically from ruxolitinib treatment.
American Psychological Association (APA)
Davis, Keith L.& Côté, Isabelle& Kaye, James A.& Mendelson, Estella& Gao, Haitao& Perez Ronco, Julian. 2015. Real-World Assessment of Clinical Outcomes in Patients with Lower-Risk Myelofibrosis Receiving Treatment with Ruxolitinib. Advances in Hematology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1052448
Modern Language Association (MLA)
Davis, Keith L.…[et al.]. Real-World Assessment of Clinical Outcomes in Patients with Lower-Risk Myelofibrosis Receiving Treatment with Ruxolitinib. Advances in Hematology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1052448
American Medical Association (AMA)
Davis, Keith L.& Côté, Isabelle& Kaye, James A.& Mendelson, Estella& Gao, Haitao& Perez Ronco, Julian. Real-World Assessment of Clinical Outcomes in Patients with Lower-Risk Myelofibrosis Receiving Treatment with Ruxolitinib. Advances in Hematology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1052448
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052448