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Prospects of Vitamin C as an Additive in Plasma of Stored Blood
Joint Authors
Vani, R.
Soumya, R.
Carl, H.
Chandni, V. A.
Neha, K.
Pankhuri, B.
Trishna, S.
Vatsal, D. P.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
There is a dire necessity to improve blood storage and prolong shelf-life of blood.
Very few studies have focused on oxidative stress (OS) in blood and its influence on plasma with storage.
This study attempts to (i) elucidate the continuous changes occurring in plasma during storage through oxidant levels and antioxidant status and (ii) evaluate the influence of vitamin C (VC) as an additive during blood storage.
Blood was drawn from male Wistar rats and stored for 25 days at 4°C.
Blood samples were divided into control and experimental groups.
Plasma was isolated every 5 days and the OS markers, antioxidant enzymes, lipid peroxidation, and protein oxidation products, were studied.
Catalase activity increased in all groups with storage.
Lipid peroxidation decreased in VC (10) but was maintained in VC (30) and VC (60).
Although there were variations in all groups, carbonyls were maintained towards the end of storage.
Advanced oxidation protein products (AOPP) increased in VC (30) and were maintained in VC (10) and VC (60).
Sulfhydryls were maintained in all groups.
Vitamin C could not sufficiently attenuate OS and hence, this opens the possibilities for further studies on vitamin C in combination with other antioxidants, in storage solutions.
American Psychological Association (APA)
Vani, R.& Soumya, R.& Carl, H.& Chandni, V. A.& Neha, K.& Pankhuri, B.…[et al.]. 2015. Prospects of Vitamin C as an Additive in Plasma of Stored Blood. Advances in Hematology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1052452
Modern Language Association (MLA)
Vani, R.…[et al.]. Prospects of Vitamin C as an Additive in Plasma of Stored Blood. Advances in Hematology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1052452
American Medical Association (AMA)
Vani, R.& Soumya, R.& Carl, H.& Chandni, V. A.& Neha, K.& Pankhuri, B.…[et al.]. Prospects of Vitamin C as an Additive in Plasma of Stored Blood. Advances in Hematology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1052452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052452