Ultrafine Resveratrol Particles: Supercritical Antisolvent Preparation and Evaluation In Vitro and In Vivo

Abstract EN

Ultrafine resveratrol (u-Res) particles were prepared through the SAS process.

The orthogonal method was used to optimize the factors of the SAS process.

The size of u-Res reached 0.68 μm under the optimum conditions.

The characterization of the u-Res particles was tested by many analysis methods.

The chemical structure of Res was unaffected by the SAS process.

The degree of crystallinity of the u-Res particles greatly reduced.

The purity of the u-Res particles increased from 98.5% to 99.2% during the SAS process.

The u-Res particles had greater saturation solubility and dissolution rate than the raw-Res (r-Res) particles.

The radical scavenging activity and bioavailability of the u-Res in vivo were 1.9 times of the r-Res.