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Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations
Joint Authors
Koch, Todd A.
Myers, Jennifer
Goodnough, Lawrence Tim
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered.
Methods.
We first individually analyzed 5 clinical studies, averaging the total iron deficit across all patients utilizing a modified Ganzoni formula; we then similarly analyzed 2 larger clinical studies.
For the second of the larger studies (Study 7), we also compared the efficacy and retreatment requirements of a cumulative dose of 1500 mg ferric carboxymaltose (FCM) to 1000 mg iron sucrose (IS).
Results.
The average iron deficit was calculated to be 1531 mg for patients in Studies 1–5 and 1392 mg for patients in Studies 6-7.
The percentage of patients who were retreated with IV iron between Days 56 and 90 was significantly (p<0.001) lower (5.6%) in the 1500 mg group, compared to the 1000 mg group (11.1%).
Conclusions.
Our data suggests that a total cumulative dose of 1000 mg of IV iron may be insufficient for iron repletion in a majority of patients with IDA and a dose of 1500 mg is closer to the actual iron deficit in these patients.
American Psychological Association (APA)
Koch, Todd A.& Myers, Jennifer& Goodnough, Lawrence Tim. 2015. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Anemia،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1053784
Modern Language Association (MLA)
Koch, Todd A.…[et al.]. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Anemia No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1053784
American Medical Association (AMA)
Koch, Todd A.& Myers, Jennifer& Goodnough, Lawrence Tim. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Anemia. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1053784
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1053784