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Spirulina platensis Lacks Antitumor Effect against Solid Ehrlich Carcinoma in Female Mice
Joint Authors
Barakat, Waleed
Elshazly, Shimaa M.
Mahmoud, Amr A. A.
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Spirulina is a blue-green alga used as a dietary supplement.
It has been shown to possess anti-inflammatory, antioxidant, and hepatoprotective properties.
This study was designed to evaluate the antitumor effect of spirulina (200 and 800 mg/kg) against a murine model of solid Ehrlich carcinoma compared to a standard chemotherapeutic drug, 5-fluorouracil (20 mg/kg).
Untreated mice developed a palpable solid tumor after 13 days.
Unlike fluorouracil, spirulina at the investigated two dose levels failed to exert any protective effect.
In addition, spirulina did not potentiate the antitumor effect of fluorouracil when they were administered concurrently.
Interestingly, their combined administration resulted in a dose-dependent increase in mortality.
The present study demonstrates that spirulina lacks antitumor effect against this model of solid Ehrlich carcinoma and increased mortality when combined with fluorouracil.
However, the implicated mechanism is still elusive.
American Psychological Association (APA)
Barakat, Waleed& Elshazly, Shimaa M.& Mahmoud, Amr A. A.. 2015. Spirulina platensis Lacks Antitumor Effect against Solid Ehrlich Carcinoma in Female Mice. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1053897
Modern Language Association (MLA)
Barakat, Waleed…[et al.]. Spirulina platensis Lacks Antitumor Effect against Solid Ehrlich Carcinoma in Female Mice. Advances in Pharmacological and Pharmaceutical Sciences No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1053897
American Medical Association (AMA)
Barakat, Waleed& Elshazly, Shimaa M.& Mahmoud, Amr A. A.. Spirulina platensis Lacks Antitumor Effect against Solid Ehrlich Carcinoma in Female Mice. Advances in Pharmacological and Pharmaceutical Sciences. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1053897
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1053897