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Evaluation of Antidiarrheal Activity of Methanolic Extract of Maranta arundinacea Linn. Leaves
Joint Authors
Rahman, Md. Khalilur
Chowdhury, Md. Ashraf Uddin
Islam, Mohammed Taufiqual
Chowdhury, Md. Anisuzzaman
Uddin, Muhammad Erfan
Sumi, Chandra Datta
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Diarrhea is one of the most common causes for thousands of deaths every year.
Therefore, identification of new source of antidiarrheal drugs becomes one of the most prominent focuses in modern research.
Our aim was to investigate the antidiarrheal and cytotoxic activities of methanolic extract of Maranta arundinacea linn.
(MEMA) leaves in rats and brine shrimp, respectively.
Antidiarrheal effect was evaluated by using castor oil-induced diarrhea, enteropooling, and gastrointestinal motility tests at 200 mg/kg and 400 mg/kg body weight in rats where the cytotoxic activity was justified using brine shrimp lethality bioassay at different concentrations of MEMA.
The extract showed considerable antidiarrheal effect by inhibiting 42.67% and 57.75% of diarrheal episode at the doses of 200 and 400 mg/kg, respectively.
MEMA also significantly p < 0.01 reduced the castor oil-induced intestinal volume (2.14 ± 0.16 to 1.61 ± 0.12 mL) in enteropooling test as well as intestinal transit (33.00 to 43.36%) in GI motility test, compared to their respective control.
These observed effects are comparable to that of standard drug loperamide (5 mg/kg).
On the other hand, in brine shrimp lethality test after 24 h, surviving brine shrimp larvae were counted and LD50 was assessed.
Result showed that MEMA was potent against brine shrimp with LD50 value of 420 µg/mL.
So the highest dose of 400 µg/mL of MEMA was not toxic to mice.
So these results indicate that bioactive compounds are present in methanolic extract of Maranta arundinacea leaves including significant antidiarrheal activity and could be accounted for pharmacological effects.
American Psychological Association (APA)
Rahman, Md. Khalilur& Chowdhury, Md. Ashraf Uddin& Islam, Mohammed Taufiqual& Chowdhury, Md. Anisuzzaman& Uddin, Muhammad Erfan& Sumi, Chandra Datta. 2015. Evaluation of Antidiarrheal Activity of Methanolic Extract of Maranta arundinacea Linn. Leaves. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1053899
Modern Language Association (MLA)
Rahman, Md. Khalilur…[et al.]. Evaluation of Antidiarrheal Activity of Methanolic Extract of Maranta arundinacea Linn. Leaves. Advances in Pharmacological and Pharmaceutical Sciences No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1053899
American Medical Association (AMA)
Rahman, Md. Khalilur& Chowdhury, Md. Ashraf Uddin& Islam, Mohammed Taufiqual& Chowdhury, Md. Anisuzzaman& Uddin, Muhammad Erfan& Sumi, Chandra Datta. Evaluation of Antidiarrheal Activity of Methanolic Extract of Maranta arundinacea Linn. Leaves. Advances in Pharmacological and Pharmaceutical Sciences. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1053899
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1053899