Antihyperglycemic Activity of Eucalyptus tereticornis in Insulin-Resistant Cells and a Nutritional Model of Diabetic Mice
Joint Authors
Guillén, Alis
Granados, Sergio
Rivas, Kevin Eduardo
Estrada, Omar
Balcázar, Norman
Echeverri, Fernando
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Eucalyptus tereticornis is a plant used in traditional medicine to control diabetes, but this effect has not been proved scientifically.
Here, we demonstrated through in vitro assays that E.
tereticornis extracts increase glucose uptake and inhibit their production in insulin-resistant C2C12 and HepG2 cells, respectively.
Furthermore, in a nutritional model using diabetic mice, the administration of ethyl acetate extract of E.
tereticornis reduced fasting glycaemia, improved tolerance to glucose, and reduced resistance to insulin.
Likewise, this extract had anti-inflammatory effects in adipose tissue when compared to control diabetic mice.
Via bioguided assays and sequential purification of the crude extract, a triterpenoid-rich fraction from ethyl acetate extracts was shown to be responsible for the biological activity.
Similarly, we identified the main compound responsible for the antihyperglycemic activity in this extract.
This study shows that triterpenes found in E.
tereticornis extracts act as hypoglycemic/antidiabetic compounds and contribute to the understanding of their use in traditional medicine.
American Psychological Association (APA)
Guillén, Alis& Granados, Sergio& Rivas, Kevin Eduardo& Estrada, Omar& Echeverri, Fernando& Balcázar, Norman. 2015. Antihyperglycemic Activity of Eucalyptus tereticornis in Insulin-Resistant Cells and a Nutritional Model of Diabetic Mice. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1053905
Modern Language Association (MLA)
Guillén, Alis…[et al.]. Antihyperglycemic Activity of Eucalyptus tereticornis in Insulin-Resistant Cells and a Nutritional Model of Diabetic Mice. Advances in Pharmacological and Pharmaceutical Sciences No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1053905
American Medical Association (AMA)
Guillén, Alis& Granados, Sergio& Rivas, Kevin Eduardo& Estrada, Omar& Echeverri, Fernando& Balcázar, Norman. Antihyperglycemic Activity of Eucalyptus tereticornis in Insulin-Resistant Cells and a Nutritional Model of Diabetic Mice. Advances in Pharmacological and Pharmaceutical Sciences. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1053905
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1053905