Antileishmanial Effect of 5,3′-Hydroxy-7,4′-dimethoxyflavanone of Picramnia gracilis Tul. (Picramniaceae) Fruit: In Vitro and In Vivo Studies
Joint Authors
Robledo, Sara M.
Cardona, Wilson
Ligardo, Karen
Henao, Jéssica
Arbeláez, Natalia
Montoya, Andrés
Alzate, Fernando
Pérez, Juan M.
Arango, Victor
Vélez, Iván D.
Sáez, Jairo
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Species of Picramnia genus are used in folk medicine to treat or prevent skin disorders, but only few species have been studied for biological activity and chemical composition.
P.
gracilis Tul.
is a native species from Central and South America and although its fruits are edible, phytochemical analysis or medicinal uses of this species are not known.
In the search of candidates to antileishmanial drugs, this work aimed to evaluate the antileishmanial activity of P.
gracilis Tul.
in in vitro and in vivo studies.
Only ethanolic extract of fruits showed leishmanicidal activity.
The majoritarian metabolite was 5,3′-hydroxy-7,4′-dimethoxyflavanone ether that exhibited high activity against L.
(V.) panamensis (EC50 17.0 + 2.8 mg/mL, 53.7 μM) and low toxicity on mammalian U-937 cells, with an index of selectivity >11.8.
In vivo studies showed that the flavanone administered in solution (2 mg/kg/day) or cream (2%) induces clinical improvement and no toxicity in hamsters with CL.
In conclusion, this is the first report about isolation of 5,3′-hydroxy-7,4′-dimethoxyflavanone of P.
gracilis Tul.
The leishmanicidal activity attributed to this flavanone is also reported for the first time.
Finally, the in vitro and in vivo leishmanicidal activity reported here for 5,3′-hydroxy-7,4′-dimethoxyflavanone offers a greater prospect towards antileishmanial drug discovery and development.
American Psychological Association (APA)
Robledo, Sara M.& Cardona, Wilson& Ligardo, Karen& Henao, Jéssica& Arbeláez, Natalia& Montoya, Andrés…[et al.]. 2015. Antileishmanial Effect of 5,3′-Hydroxy-7,4′-dimethoxyflavanone of Picramnia gracilis Tul. (Picramniaceae) Fruit: In Vitro and In Vivo Studies. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1053916
Modern Language Association (MLA)
Robledo, Sara M.…[et al.]. Antileishmanial Effect of 5,3′-Hydroxy-7,4′-dimethoxyflavanone of Picramnia gracilis Tul. (Picramniaceae) Fruit: In Vitro and In Vivo Studies. Advances in Pharmacological and Pharmaceutical Sciences No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1053916
American Medical Association (AMA)
Robledo, Sara M.& Cardona, Wilson& Ligardo, Karen& Henao, Jéssica& Arbeláez, Natalia& Montoya, Andrés…[et al.]. Antileishmanial Effect of 5,3′-Hydroxy-7,4′-dimethoxyflavanone of Picramnia gracilis Tul. (Picramniaceae) Fruit: In Vitro and In Vivo Studies. Advances in Pharmacological and Pharmaceutical Sciences. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1053916
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1053916