Archaeal MCM Proteins as an Analog for the Eukaryotic Mcm2–7 Helicase to Reveal Essential Features of Structure and Function
Joint Authors
Miller, Justin M.
Enemark, Eric J.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
In eukaryotes, the replicative helicase is the large multisubunit CMG complex consisting of the Mcm2–7 hexameric ring, Cdc45, and the tetrameric GINS complex.
The Mcm2–7 ring assembles from six different, related proteins and forms the core of this complex.
In archaea, a homologous MCM hexameric ring functions as the replicative helicase at the replication fork.
Archaeal MCM proteins form thermostable homohexamers, facilitating their use as models of the eukaryotic Mcm2–7 helicase.
Here we review archaeal MCM helicase structure and function and how the archaeal findings relate to the eukaryotic Mcm2–7 ring.
American Psychological Association (APA)
Miller, Justin M.& Enemark, Eric J.. 2015. Archaeal MCM Proteins as an Analog for the Eukaryotic Mcm2–7 Helicase to Reveal Essential Features of Structure and Function. Archaea،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1053925
Modern Language Association (MLA)
Miller, Justin M.& Enemark, Eric J.. Archaeal MCM Proteins as an Analog for the Eukaryotic Mcm2–7 Helicase to Reveal Essential Features of Structure and Function. Archaea No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1053925
American Medical Association (AMA)
Miller, Justin M.& Enemark, Eric J.. Archaeal MCM Proteins as an Analog for the Eukaryotic Mcm2–7 Helicase to Reveal Essential Features of Structure and Function. Archaea. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1053925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1053925