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Obesity Is Not Associated with Impaired Immune Response to Influenza Vaccination in HIV-Infected Persons
Joint Authors
Gowda, Charitha
McKittrick, Noah
Kim, Deborah
Kappes, Rosemarie A.
Lo Re, Vincent
Tebas, Pablo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
HIV-infected individuals demonstrate lower immunogenicity to the influenza vaccine, despite immunologic and virologic control of HIV infection.
Obesity has been previously shown to be associated with diminished antibody responses to other vaccines in HIV-uninfected persons.
However, no studies have examined if obesity is associated with diminished protective immune response to influenza vaccination among HIV-infected persons on antiretroviral therapy (ART).
Methods.
We performed a retrospective analysis of immunogenicity data from a clinical trial of inactivated, trivalent influenza vaccine.
The primary endpoint was the proportion of participants with seroconversion, defined as >4-fold increase in anti-hemagglutinin antibody titers after vaccination.
Secondary endpoints were the proportion of participants with seroprotection (defined as antibody titers of ≥1 : 40) and geometric mean hemagglutination inhibition antibody titers.
Results.
Overall, 48 (27%) participants were obese (body mass index ≥ 30 kg/m2).
Seroconversion rates were comparable between obese and nonobese subjects for all three vaccine strains.
Further, postvaccination geometric mean titers did not differ by body mass index category.
Conclusion.
Obesity was not associated with diminished antibody response to influenza vaccination in a sample of healthy HIV-infected persons.
American Psychological Association (APA)
Gowda, Charitha& McKittrick, Noah& Kim, Deborah& Kappes, Rosemarie A.& Lo Re, Vincent& Tebas, Pablo. 2015. Obesity Is Not Associated with Impaired Immune Response to Influenza Vaccination in HIV-Infected Persons. AIDS Research and Treatment،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1053966
Modern Language Association (MLA)
Gowda, Charitha…[et al.]. Obesity Is Not Associated with Impaired Immune Response to Influenza Vaccination in HIV-Infected Persons. AIDS Research and Treatment No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1053966
American Medical Association (AMA)
Gowda, Charitha& McKittrick, Noah& Kim, Deborah& Kappes, Rosemarie A.& Lo Re, Vincent& Tebas, Pablo. Obesity Is Not Associated with Impaired Immune Response to Influenza Vaccination in HIV-Infected Persons. AIDS Research and Treatment. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1053966
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1053966