Long-Term Consequences of Hepatitis C Viral Clearance on the CD4 (+) T Cell Lymphocyte Course in HIVHCV Coinfected Patients
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-26
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The long-term impact of pegylated-interferon plus ribavirin treatment outcome on CD4 T cell course in patients coinfected with human immunodeficiency virus and hepatitis C virus is largely unclear in the literature.
The aim of this study was to investigate the impact of HCV-RNA clearance by standard anti-HCV therapy on long-term CD4 cells recovery in HIV/HCV patients on successful combined antiretroviral therapy.
We retrospectively enrolled HIV/HCV-coinfected patients on HIV medications and treated for hepatitis C.
CD4 + T cell counts were registered at baseline and after hepatitis C therapy.
Multiple linear regression analysis was performed to identify independent predictors of CD4 + T cell change following the anti-HCV treatment outcome.
Of the 116 patients enrolled, 54 (46.6%) reached a sustained virological response.
During a follow-up of 24 months, the SVR group showed a mean annual increase in CD4 + T cell from baseline of 84 cells/ll at 1 year and of a further 38 cells/ll within the second year ( P = 0.01 , 0.001, resp.).
An insignificant mean increase of 77 cells/ll occurred in the non-SVR group within month 24 ( P = 0.06 ).
Variables associated with greater CD4 gains were higher nadir, lower preinterferon CD4 counts, and lower body mass index (BMI).
American Psychological Association (APA)
Dazley, J.& Sison, R.& Slim, J.. 2015. Long-Term Consequences of Hepatitis C Viral Clearance on the CD4 (+) T Cell Lymphocyte Course in HIVHCV Coinfected Patients. AIDS Research and Treatment،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1053967
Modern Language Association (MLA)
Dazley, J.…[et al.]. Long-Term Consequences of Hepatitis C Viral Clearance on the CD4 (+) T Cell Lymphocyte Course in HIVHCV Coinfected Patients. AIDS Research and Treatment No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1053967
American Medical Association (AMA)
Dazley, J.& Sison, R.& Slim, J.. Long-Term Consequences of Hepatitis C Viral Clearance on the CD4 (+) T Cell Lymphocyte Course in HIVHCV Coinfected Patients. AIDS Research and Treatment. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1053967
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1053967