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Efficacy of Once Daily DarunavirRitonavir in PI-Naïve, NNRTI-Experienced Patients in the ODIN Trial
Joint Authors
van Delft, Yvon
Geretti, Anna Maria
Moeketsi, Mathe
Demasi, Ralph
Mohammed, Perry
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
An exploratory subanalysis of the ODIN trial was performed to evaluate the efficacy of darunavir/ritonavir (DRV/r) 800/100 mg OD versus 600/100 mg BID in patients who were NNRTI-experienced but PI-naïve.
Methods.
ODIN was a phase III, 48-week study comparing DRV/r OD versus BID in 590 treatment-experienced patients with no DRV resistance-associated mutations (RAMs) at screening.
Patients received DRV/r 800/100 mg OD or DRV/r 600/100 mg BID plus ≥2 NRTIs.
Of the 590 patients randomized, 272 (46%) were NNRTI-experienced but PI-naïve.
Results.
Overall, 272 patients received DRV/r OD n = 135 or BID n = 137 plus ≥2 optimised NRTIs.
The mean age was 39 years; 35% were female; 27% were Black, 24% Caucasian, 26% Oriental/Asian, and 23% other races; 17% were recruited in South Africa; and 48% had non-B HIV-1 subtypes.
Mean baseline plasma HIV-1 RNA load was 4.10 log 10 copies/mL; median CD4 cell count was 258 cells/μL.
At week 48, 111/135 (82%) of DRV/r OD and 109/137 (80%) of DRV/r BID patients achieved an HIV-1 RNA load <50 copies/mL.
No patient developed primary PI RAMs.
Conclusion.
DRV/r 800/100 mg OD in combination with ≥2 optimised NRTIs led to virological suppression <50 copies/mL in 82% of NNRTI-experienced, PI-naïve patients by week 48.
American Psychological Association (APA)
Geretti, Anna Maria& Moeketsi, Mathe& Demasi, Ralph& van Delft, Yvon& Mohammed, Perry. 2015. Efficacy of Once Daily DarunavirRitonavir in PI-Naïve, NNRTI-Experienced Patients in the ODIN Trial. AIDS Research and Treatment،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1053972
Modern Language Association (MLA)
Geretti, Anna Maria…[et al.]. Efficacy of Once Daily DarunavirRitonavir in PI-Naïve, NNRTI-Experienced Patients in the ODIN Trial. AIDS Research and Treatment No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1053972
American Medical Association (AMA)
Geretti, Anna Maria& Moeketsi, Mathe& Demasi, Ralph& van Delft, Yvon& Mohammed, Perry. Efficacy of Once Daily DarunavirRitonavir in PI-Naïve, NNRTI-Experienced Patients in the ODIN Trial. AIDS Research and Treatment. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1053972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1053972