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The Role of Interferon in the Management of BCG Refractory Nonmuscle Invasive Bladder Cancer
Joint Authors
Maranchie, Jodi K.
Correa, Andres F.
Theisen, Katherine
Ferroni, Matthew
Davies, Benjamin J.
Gingrich, Jeffrey R.
Hrebinko, Ronald L.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Thirty to forty percent of patients with high grade nonmuscle invasive bladder cancer (NMIBC) fail to respond to intravesical therapy with bacillus Calmette-Guerin (BCG).
Interferon-α2B plus BCG has been shown to be effective in a subset of patients with NMIBC BCG refractory disease.
Here we present a contemporary series on the effectiveness and safety of intravesical BCG plus interferon-α2B therapy in patients with BCG refractory NMIBC.
Methods.
From January of 2005 to April of 2014 we retrospectively found 44 patients who underwent induction with combination IFN/BCG for the management of BCG refractory NMIBC.
A chart review was performed to assess initial pathological stage/grade, pathological stage/grade at the time of induction, time to IFN/BCG failure, pathological stage/grade at failure, postfailure therapy, and current disease state.
Results.
Of the 44 patients who met criteria for the analysis.
High risk disease was found in 88.6% of patients at induction.
The 12-month and 24-month recurrence-free survival were 38.6% and 18.2%, respectively.
25 (56.8%) ultimately had disease recurrence.
Radical cystectomy was performed in 16 (36.4%) patients.
Conclusion.
Combination BCG plus interferon-α2B remains a reasonably safe alternative treatment for select patients with BCG refractory disease prior to proceeding to radical cystectomy.
American Psychological Association (APA)
Correa, Andres F.& Theisen, Katherine& Ferroni, Matthew& Maranchie, Jodi K.& Hrebinko, Ronald L.& Davies, Benjamin J.…[et al.]. 2015. The Role of Interferon in the Management of BCG Refractory Nonmuscle Invasive Bladder Cancer. Advances in Urology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1053997
Modern Language Association (MLA)
Correa, Andres F.…[et al.]. The Role of Interferon in the Management of BCG Refractory Nonmuscle Invasive Bladder Cancer. Advances in Urology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1053997
American Medical Association (AMA)
Correa, Andres F.& Theisen, Katherine& Ferroni, Matthew& Maranchie, Jodi K.& Hrebinko, Ronald L.& Davies, Benjamin J.…[et al.]. The Role of Interferon in the Management of BCG Refractory Nonmuscle Invasive Bladder Cancer. Advances in Urology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1053997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1053997