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Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide
Joint Authors
Wahba, M. A.
El-Tabl, Abdou Saad
Mohamed Abd El-Waheed, Moshira
Abd El-Halim Abou El-Fadl, Nahla
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-25
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Novel metal(II) complexes derived from 2-hydroxy-N′-((Z)-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide ligand (H2L) were synthesized and characterized by elemental and thermal analyses (DTA and TGA), IR, UV-VIS, 1H-NMR, ESR and mass spectroscopy, magnetic susceptibilities, and conductivities measurements.
The complexes adopt distorted octahedral geometry.
The ESR spectra of the solid copper(II) complexes are characteristic to d9 configuration and have an axial symmetry type of a d(x2-y2) ground state.
The g values confirmed the tetragonal octahedral geometry with a considerably ionic or covalent environment.
The cytotoxic activity of the ligand and its metal complexes showed potent cytotoxicity effect against growth of human liver cancer HepG2 cell lines compared to the clinically used Sorafenib (Nexavar).
American Psychological Association (APA)
El-Tabl, Abdou Saad& Mohamed Abd El-Waheed, Moshira& Wahba, M. A.& Abd El-Halim Abou El-Fadl, Nahla. 2015. Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide. Bioinorganic Chemistry and Applications،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1054038
Modern Language Association (MLA)
El-Tabl, Abdou Saad…[et al.]. Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide. Bioinorganic Chemistry and Applications No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1054038
American Medical Association (AMA)
El-Tabl, Abdou Saad& Mohamed Abd El-Waheed, Moshira& Wahba, M. A.& Abd El-Halim Abou El-Fadl, Nahla. Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide. Bioinorganic Chemistry and Applications. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1054038
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054038