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Ferrocene-Based Bioactive Bimetallic Thiourea Complexes: Synthesis and Spectroscopic Studies
Joint Authors
Butler, Ian S.
Ali, Shafqat
Yasin, Ghulam
Zuhra, Zareen
Wu, Zhanpeng
Badshah, Amin
Din, Imtiaz ud
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Bioactive 1,1′-(4,4′-di-ferrocenyl)di-phenyl thiourea and various metal complexes of this ligand have been successfully synthesized and characterized by using physicoanalytical techniques such as FT-IR and multinuclear (1H and 13C) NMR spectroscopy along with melting point and elemental analyses.
The interaction of the synthesized compounds with DNA has been investigated by using cyclic voltammetric and viscometric measurements.
The intercalation of the complexes into the double helix structure of DNA is presumably occurring.
Viscosity measurements of the complexes have shown that there is a change in length and this is regarded as the least ambiguous and the most critical test of the binding model in solution.
The relative potential of the complexes as anti-bacterial, antifungal, and inhibition agents against the enzyme, alkaline phosphatase EC 3.1.3.1, has also been assessed and the complexes were found to be active inhibitors.
American Psychological Association (APA)
Ali, Shafqat& Yasin, Ghulam& Zuhra, Zareen& Wu, Zhanpeng& Butler, Ian S.& Badshah, Amin…[et al.]. 2015. Ferrocene-Based Bioactive Bimetallic Thiourea Complexes: Synthesis and Spectroscopic Studies. Bioinorganic Chemistry and Applications،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054045
Modern Language Association (MLA)
Ali, Shafqat…[et al.]. Ferrocene-Based Bioactive Bimetallic Thiourea Complexes: Synthesis and Spectroscopic Studies. Bioinorganic Chemistry and Applications No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054045
American Medical Association (AMA)
Ali, Shafqat& Yasin, Ghulam& Zuhra, Zareen& Wu, Zhanpeng& Butler, Ian S.& Badshah, Amin…[et al.]. Ferrocene-Based Bioactive Bimetallic Thiourea Complexes: Synthesis and Spectroscopic Studies. Bioinorganic Chemistry and Applications. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054045
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054045