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Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) Complexes
Joint Authors
Huang, Yanmin
Kong, Erbin
Gan, Chunfang
Liu, Zhiping
Lin, Qifu
Cui, Jianguo
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Steroidal compounds exhibit particular physiological activities.
In this paper, some steroidal thiosemicarbazones platinum (Pt(II)) complexes were synthesized by the condensation of steroidal ketones with thiosemicarbazide using estrone, chenodeoxycholic acid, and 7-deoxycholic acid as starting materials and complexation of steroidal thiosesemicarbazones with Pt(II).
The complexes were characterized by IR, NMR, and MS, and their antiproliferative activities were evaluated.
The results showed that some steroidal thiosemicarbazones platinum (Pt(II)) complexes displayed moderate cytotoxicity to HeLa and Bel-7404 cells.
Thereinto, complex 6 showed an excellent inhibited selectivity to HeLa cells with an IC50 value of 9.2 μM and SI value of 21.7.
At the same time, all compounds were almost inactive to HEK293T (normal kidney epithelial cells).
The information obtained from the studies may be useful for the design of novel chemotherapeutic drugs.
American Psychological Association (APA)
Huang, Yanmin& Kong, Erbin& Gan, Chunfang& Liu, Zhiping& Lin, Qifu& Cui, Jianguo. 2015. Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) Complexes. Bioinorganic Chemistry and Applications،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054053
Modern Language Association (MLA)
Huang, Yanmin…[et al.]. Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) Complexes. Bioinorganic Chemistry and Applications No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054053
American Medical Association (AMA)
Huang, Yanmin& Kong, Erbin& Gan, Chunfang& Liu, Zhiping& Lin, Qifu& Cui, Jianguo. Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) Complexes. Bioinorganic Chemistry and Applications. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054053
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054053