Oxaliplatin Analogues with Carboxy Derivatives of Boldine with Enhanced Antioxidant Activity
Joint Authors
Mellado, Marco
Jara, Carlos
Astudillo, David
Villena, Joan
Reveco, Patricio G.
Thomet, Franz A.
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A new oxaliplatin analog [Pt(dach)(L5)] (1) was synthesized and characterized as a continuation of a study of the previously reported [Pt(dach)(L6)] (2), where dach = (1R,2R)-diaminocyclohexane, L5 = 3-carboxyboldine, and L6 = 3-carboxypredicentrine.
Compounds 1 and 2 exhibited a substantially enhanced antioxidant activity compared to oxaliplatin (130 and 30 times for 1 and 13 and 4 times for 2 using the DPPH and FRAP assays, resp.).
In addition, 1 and 2 exhibited cytotoxic activity in the same range as oxaliplatin toward the two human tumor cell lines (MCF-7 and HT-29) studied and two to four times lower activity in the human colon nontumor cell line (CCD-841).
Preadministration of L5 or L6 to the colon tumor (HT-29) and the colon nontumor (CCD-841) cell lines prior to oxaliplatin addition increased the viability of the nontumor cell line to a greater extent than that of the tumor cell line.
American Psychological Association (APA)
Mellado, Marco& Jara, Carlos& Astudillo, David& Villena, Joan& Reveco, Patricio G.& Thomet, Franz A.. 2015. Oxaliplatin Analogues with Carboxy Derivatives of Boldine with Enhanced Antioxidant Activity. Bioinorganic Chemistry and Applications،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054060
Modern Language Association (MLA)
Mellado, Marco…[et al.]. Oxaliplatin Analogues with Carboxy Derivatives of Boldine with Enhanced Antioxidant Activity. Bioinorganic Chemistry and Applications No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054060
American Medical Association (AMA)
Mellado, Marco& Jara, Carlos& Astudillo, David& Villena, Joan& Reveco, Patricio G.& Thomet, Franz A.. Oxaliplatin Analogues with Carboxy Derivatives of Boldine with Enhanced Antioxidant Activity. Bioinorganic Chemistry and Applications. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054060
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054060